• 专利标题:   Polyurethane nanofiber scaffold containing nano graphene oxide useful for soft tissue regeneration, prepared by electrospinning by mixing nano graphene oxide solution with silane coupling agent and polyurethane solution.
  • 专利号:   KR2021070426-A, KR2361455-B1
  • 发明人:   KIM H, JIN K K, PARK J H, ERDENEBILEG U, LEE J, LEE H, KNOWLES J C, JO S B
  • 专利权人:   UNIV DANKOOK IND ACADEMIC COOP FOUND
  • 国际专利分类:   A61L027/18, A61L027/44, A61L027/56
  • 专利详细信息:   KR2021070426-A 15 Jun 2021 A61L-027/56 202159 Pages: 15
  • 申请详细信息:   KR2021070426-A KR159624 04 Dec 2019
  • 优先权号:   KR159624

▎ 摘  要

NOVELTY - Polyurethane nanofiber scaffold containing nano graphene oxide (nGO), prepared by electrospinning by mixing a nano graphene oxide solution with a silane coupling agent and a polyurethane solution, is claimed. USE - The polyurethane nanofiber scaffold is useful for soft tissue regeneration (claimed). ADVANTAGE - The scaffold improves mechanical properties such as hydrophilicity, elasticity and stress relaxation ability, and has a soft tissue regeneration effect such as muscle without cytotoxicity; is suitable for soft tissues such as cardiac muscle and skeletal muscle that have very elastic properties. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) preparing a nanofiber scaffold, comprising (a) adding a silane coupling agent to the graphene oxide solution and the polyurethane solution, (b) mixing each solution to which the silane coupling agent of (a) is added by ultrasonication to disperse the solution homogeneously, and (c) collecting the fibers obtained by electrospinning the mixed solution of (b); and (2) composition for soft tissue regeneration, comprising nanofiber scaffold as an active ingredient. DESCRIPTION OF DRAWING(S) - The drawing shows the preparation and physicochemical properties of PU-nGO nanofibers.