• 专利标题:   Producing microcapsule in pharmaceutical, cosmetic, nutraceutical, paper, paint, coating, biological, industrial or agricultural applications, by contacting active ingredient or its inactive precursor with surface-reacted calcium carbonate and encasing calcium carbonate with multilayer shell.
  • 专利号:   WO2021259777-A1, EP3928859-A1, CN115916392-A, EP4168171-A1, US2023201126-A1
  • 发明人:   SCHOELKOPF J, HILTYVANCURA F M, KIRYUKHIN M
  • 专利权人:   OMYA INT AG, OMYA INT AG, OMYA INT AG
  • 国际专利分类:   A01N025/28, A23P010/30, A61K008/11, A61K009/50, B01J013/10, B01J013/22, A61K009/48
  • 专利详细信息:   WO2021259777-A1 30 Dec 2021 202208 Pages: 72 English
  • 申请详细信息:   WO2021259777-A1 WOEP066576 18 Jun 2021
  • 优先权号:   EP181641, CN80044292

▎ 摘  要

NOVELTY - Process for producing microcapsule comprising an active ingredient or its inactive precursor, involves (a) providing a surface-reacted calcium carbonate, where the surface-reacted calcium carbonate is a reaction product of natural ground calcium carbonate or precipitated calcium carbonate with carbon dioxide and one or more hydronium ions ion donors, where the carbon dioxide is formed in situ by the hydronium ion donors treatment, (b) providing an active ingredient or its inactive precursor, (c) contacting the active ingredient or its inactive precursor with the surface-reacted calcium carbonate to obtain a loaded surface-reacted calcium carbonate, and (d) encasing the loaded surface-reacted calcium carbonate with a multilayer shell by consecutively depositing at least two complementary layers using layer-by-layer assembly onto the loaded surface-reacted calcium carbonate. USE - The process is useful for producing microcapsule in pharmaceutical, cosmetic, nutraceutical, paper, paint, coating, biological, industrial or agricultural applications, or used as template for encapsulating an active ingredient or its inactive precursor using layer-by-layer assembly, or producing product chosen from a pharmaceutical product, a foodstuff, a feedstuff, a food supplement, a feed supplement, a cosmetic product, a paper product, a painting product, a coating product, or an agricultural product (all claimed). ADVANTAGE - The process rapidly produces microcapsule. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a microcapsule, which comprises an active ingredient or its inactive precursor obtainable by the process.