▎ 摘　　要

NOVELTY - Vascular access port system comprises an implantable indwelling device (400) for in-situ detection of circulating cell-free tumor DNA (ctDNA), where the indwelling device comprises a reservoir and a catheter (405) extending from the reservoir (410), the catheter being configured to interface with a circulatory system of a subject to access a bodily fluid in the circulatory system of the subject, and a DNA detector (425) comprising a set of DNA probes positioned at the catheter and reservoir, the set of DNA probes comprising a normal DNA strand complementary to a ctDNA strand, and a set of sensors configured to detect signals corresponding to DNA hybridizations at DNA probes in the set of DNA probes. USE - Vascular access port system for detecting circulating ctDNA in situ in subject (claimed). ADVANTAGE - The vascular access port system provides simple, accurate and highly sensitive methods to detect ctDNA. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method of detecting (ctDNA) in situ in subject using a vascular access port system, which involves implanting an indwelling device in the subject, the indwelling device comprising a reservoir and a catheter extending from the reservoir, the catheter being configured to interface, when implanted, with a circulatory system of the subject to access the subject s blood; a DNA detector comprising a set of DNA probes situated on the catheter and reservoir, the set of DNA probes comprising a first DNA probe with a first normal DNA strand complementary to a first ctDNA strand, and a second DNA probe with a second normal DNA strand complementary to the first ctDNA strand or to a second ctDNA strand; a set of sensors configured to detect electrical signals corresponding to DNA hybridizations at the DNA probes, the set of sensors comprising at least a first sensor situated at the first DNA probe and configured to detect signals corresponding to hybridization of the first normal DNA strand to the first ctDNA strand, and a second sensor situated at the second DNA probe and configured to detect signals corresponding to hybridization of the second normal DNA strand to the first ctDNA strand or to the second ctDNA strand; and a wireless transmitter configured to transmit detected signals to a remote computing device. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of vascular access port system. Indwelling device (400) Catheter (405) Reservoir (410) DNA detector (425)