▎ 摘　　要

NOVELTY - A smart electric heating dressing with temperature-controlled and segmented drug delivery comprises an electric heating conductive fabric, the conductive fabric has coating areas for independently controlling heating, each of the coating area is provided with a drug dressing layer, and the drug dressing layer includes a gel matrix, the temperature-sensitive drug-loaded microgel coated in the gel matrix, and the drug solution loaded in the temperature-sensitive drug-loaded microgel, and the types of drug solutions loaded on the temperature-sensitive drug-loaded microgels in different coated regions are different. USE - The smart electric heating dressing with temperature-controlled and segmented drug delivery is used for treating wound with unhealed or non-healing trend including sore, diabetic foot ulcer, lower limb artery and vein ulcer. ADVANTAGE - The dressing can stimulate the temperature-sensitive drug-loading micro-gel in different areas to generate phase transition, to release different medicines and medicine types according to the periodic demand of wound healing, dosage and release time can be controlled, shortens the wound healing period, improves treatment effect, avoids the need to change frequently, avoids changing the wound secondary infection that the dressing in-process arouses, avoids inconvenience to the patient to change dressings many times and avoids changing dressings at every turn that probably increase the pain of patient. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a preparation method of the smart electric heating dressing with temperature-controlled and segmented drug delivery comprising (S1) soaking a fabric into a dispersion liquid containing a carbon material, taking out the fabric, penetrating the fabric through a roller to realize pad dyeing, drying the fabric, and repeating the pad dyeing for one time to prepare a conductive fabric, (S2) adding two temperature-sensitive comonomers, sodium alginate, initiator and accelerator to the inorganic hectorite aqueous dispersion, polymerizing for 10-24 hours at room temperature, dripping the obtained polymer gradually into a calcium chloride aqueous solution to form spherical microgel, regulating the molar ratio of the two temperature-sensitive comonomers to obtain the spherical microgel with different response temperatures, washing the spherical microgel with deionized water, filtering, freeze-drying, putting the freeze-dried spherical microgel with different response temperatures into different drug solutions respectively, and swelling for 12-24 hours to prepare various temperature-sensitive drug-loaded microgels loaded with different drug solutions, and (S3) adding acrylamide monomer, initiator and accelerator to the inorganic hectorite aqueous dispersion to form a pre-polymerization solution, adding the temperature-sensitive drug-loaded microgel, coating the pre-polymerization solution on the surface of the conductive fabric, corresponding the temperature-sensitive drug-loaded microgel loaded with different types of drug solutions to different coating areas, and reacting for 8-24 hours at room temperature to enable the pre-polymerization solution to form a gel matrix coated with the temperature-sensitive drug-loaded microgel through a polymerization reaction to obtain the smart electric heating dressing with temperature-controlled and segmented drug delivery.