▎ 摘　　要

NOVELTY - Preparing multifunctional nanocarrier folic acid-modified erythrocyte membrane-doped graphene oxide-based metal-organic frameworks (FA-EM-doped GO-MOF) involves (i) adding graphene oxide (GO) and tetrakis(4-carboxyphenyl)porphyrin (TCPP) into a buffer solution, ultrasonically treating and drying to obtain GO-TCPP for storage, (ii) adding iron(III) nitrate nonahydrate and sodium acetate trihydrate to an organic solution, performing refluxing reaction, and centrifuging to collect the solid precipitate iron acetate compound (I), (iii) adding the compound (I) and GO-TCPP to an organic solution, adding formic acid, uniformly mixing and reacting the mixed solution to obtain GO-MOF nanocarrier, (iv) adding 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-folate (DSPE-PEG-FA) to red blood cell solution and stirring and (v) resuspending the obtained FA-EM in buffer, adding GO-MOF nanocarrier obtained in step (iii) and stirring to obtain the product. USE - Method for preparing multifunctional nanocarrier FA-EM-doped GO-MOF for preparing contrast agents for NMR, environment-responsive drug-loading agents, and photothermal therapy and photodynamic therapy agents (all claimed), promoting the release of tumor-related antigens, stimulating antigen-presenting cells, and inducing an anti-tumor immune response in the body, as a contrast agent for MRI and providing catalase-like activity. ADVANTAGE - The method avoids the immune clearance of the body and realizes the targeted delivery of drugs, converts light energy into heat energy, generates heat at the tumor site, transfers the heat energy to the surrounding oxygen and generates reactive oxygen species (ROS) to induce tumor death. DETAILED DESCRIPTION - Preparing multifunctional nanocarrier folic acid-modified erythrocyte membrane-doped graphene oxide-based metal-organic frameworks (FA-EM-doped GO-MOF) involves (i) adding graphene oxide (GO) and tetrakis(4-carboxyphenyl)porphyrin (TCPP) into a buffer solution, ultrasonically treating and drying to obtain GO-TCPP for storage, (ii) adding iron(III) nitrate nonahydrate and sodium acetate trihydrate to an organic solution, performing refluxing reaction, and centrifuging to collect the solid precipitate iron acetate compound of formula: (Fe3O(CH3COO)6(H2O)3)(CH3COO) (I), (iii) adding the compound (I) and GO-TCPP to an organic solution, adding formic acid, uniformly mixing and reacting the mixed solution at high temperature to obtain GO-MOF nanocarrier, (iv) adding 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-folate (DSPE-PEG-FA) to red blood cell solution and stirring to obtain DSPE-PEG-FA modified red blood cell membrane FA-EM and (v) resuspending the FA-EM in buffer, adding GO-MOF nanocarrier obtained in step (iii) to the above solution and stirring to obtain the product. An INDEPENDENT CLAIM is included for a therapeutic drug for tumors uses the multifunctional nanocarrier FA-EM-doped GO-MOF as the carrier and loaded with anti-tumor drugs.