• 专利标题:   Obtaining covalently modified graphene used in analyte detector device for forming portion of the anchoring surface of bio-receptor molecules of analytes to be detected, involves applying voltage of 10 volts and generating electric field.
  • 专利号:   WO2021160911-A1, ES2848798-A1, ES2848798-B2, CN115443251-A, EP4105176-A1, US2023072480-A1
  • 发明人:   ALVAREZ CASTILLO A L, QUESADA SANCHEZ S J, BORRAS RODRIGO F, COYA PARRAGA C, COYA P C, BORRAS R F, QUESADA S S J, ALVAREZ C A L
  • 专利权人:   UNIV REY JUAN CARLOS, UNIV REY JUAN CARLOS, UNIV REY JUAN CARLOS
  • 国际专利分类:   C01B032/182, C01B032/194, C12Q001/00, G01N033/551
  • 专利详细信息:   WO2021160911-A1 19 Aug 2021 C01B-032/182 202174 Pages: 40 Spanish
  • 申请详细信息:   WO2021160911-A1 WOES070088 09 Feb 2021
  • 优先权号:   ES030111, CN80020021

▎ 摘  要

NOVELTY - Obtaining covalently modified graphene involves applying a voltage of 10 volts and generating an electric field in an area of the graphene surface in the presence of water and a substance that, in water, or in the presence of the electric field generated by the voltage, gives rise to one or more ions and/or one or more radicals, optionally washing the graphene and repeat the first and second step successively in another area of the graphene surface to be modified, different from the area or areas in which the steps are already carried out with the same or a different substance that, in water, or in water and in the presence of the electric field generated by the voltage, gives rise to one or more ions and/or one or more radicals. USE - Method for obtaining covalently modified graphene used in analyte detector device for forming portion of the anchoring surface of bio-receptor molecules of analytes to be detected (claimed). ADVANTAGE - The covalently modified graphene comprises functional groups for binding to bioreceptor molecules in the analyte detector device for detecting the analytes. DETAILED DESCRIPTION - Obtaining covalently modified graphene involves applying a voltage of 10 volts and generating an electric field in an area of the graphene surface in the presence of water and a substance that, in water, or in the presence of the electric field generated by the voltage, gives rise to one or more ions and/or one or more radicals, optionally washing the graphene and repeat the first and second step successively in another area of the graphene surface to be modified, different from the area or areas in which the steps are already carried out with the same or a different substance that, in water, or in water and in the presence of the electric field generated by the voltage, gives rise to one or more ions and/or one or more radicals. The substance that, in water, or in water and in the presence of an electric field, gives rise to one or more ions or radicals, is selected from a compound that, in water, and in the presence of an electric field it gives rise to a radical selected from superoxide radical, alkoxyl radical, aroxyl radical, peroxyl radical, aminoxyl radical, nitrogen monoxide radical, nitrogen dioxide radical, nitrosonium cation, nitrene radical, halogen radical, alkyl radical, aryl radical, carbene radical or cetyl radical; or a compound comprising one or more functional groups than in water, or in water and in the presence of an electric field, give rise to the radical; or a compound that, in water and in the presence of an electric field, gives rise to a cation, where the cation is selected from metal cation, ammonium cation, nitronium cation, carbocation, diazonium cation or guanidine cation; or a compound comprising functional groups that, in water, or in water and in the presence of an electric field, give rise to the cation; and a compound that, in water, or in water and in the presence of an electric field, gives rise to an anion, where the anion is selected from peroxide, alkoxide, phenolate, carboxylate, azide, carbonate, bicarbonate, borate, bromate, iodate, cyanate, isocyanate, cyanide, nitrate, nitrite, halide, sulfate, bisulfate, thiosulfate, sulfite, bisulfite, sulfide, bisulfide, disulfide, phosphate, phosphite, acid phosphate, diacid phosphate and silicate; or a compound comprising one or more functional groups that, in water, or in water and in the presence of an electric field, give rise to the anion or a compound comprising one or more functional groups that, in water, or in water and in the presence of an electric field, that give rise to the anion. An INDEPENDENT CLAIM is included for an analyte detector device comprising covalently modified graphene.