• 专利标题:   Stable three-dimensional material matrix used in cell culture systems, has graphene-containing material, polymer crosslinked with graphene-containing material, and salt crystals integrated with graphene-containing material and polymer.
  • 专利号:   US2021214678-A1
  • 发明人:   DARLAND D, ZHAO J X, ZHANG Y
  • 专利权人:   DARLAND D, ZHAO J X, ZHANG Y, UNIV NORTH DAKOTA
  • 国际专利分类:   C12N005/00
  • 专利详细信息:   US2021214678-A1 15 Jul 2021 C12N-005/00 202176 English
  • 申请详细信息:   US2021214678-A1 US214195 26 Mar 2021
  • 优先权号:   US469367P, US214195

▎ 摘  要

NOVELTY - Stable three-dimensional material matrix comprises a graphene-containing material; a polymer, where the polymer is crosslinked with the graphene-containing material; and salt crystals integrated with the graphene-containing material and polymer. USE - The stable three-dimensional material matrix and the three-dimensional porous graphene mesh are useful in cell culture systems. ADVANTAGE - The graphene oxide three-dimensional meshes have tunable hardness and porosity for application in cell culture systems. Methods of preparing the meshes can be simple, easily reproducible, low cost, and amenable to expanded production. The combination of graphene-based materials with polymers further improves the resulting material's properties. The combination of graphene-based materials with chitosan, collagen, and some other polymers has shown improved properties for adhesion and differentiation of neural stem cells. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a three-dimensional porous graphene mesh comprising a graphene-containing material; and a polymer, where the polymer is crosslinked with the graphene-containing material such that the Young's Modulus of the mesh is at least about 5 GPa.