• 专利标题:   Producing magnetic resonance imaging contrast agent used for obtaining and monitoring image of angiogenesis of blood vessels, by treating carbon-13-containing saccharide solution with microwaves, and preparing contrast agent comprising carbon-13-containing graphene quantum dots.
  • 专利号:   WO2022045748-A1, KR2022026516-A, CN115989083-A, EP4197562-A1
  • 发明人:   HONG B H, JUNG Y J, PARK J B, JEONG Y J, PIAO Z, CHUNG Y, HONG B
  • 专利权人:   BIOGRAPHENE INC, UNIV SEOUL NAT R DB FOUND, BIO GRAPHENE INC, SNU R DB FOUND, BIOGRAPHENE INC, UNIV SEOUL NAT R DB FOUND
  • 国际专利分类:   A61K051/12, B01J019/12
  • 专利详细信息:   WO2022045748-A1 03 Mar 2022 202231
  • 申请详细信息:   WO2022045748-A1 WOKR011324 25 Aug 2021
  • 优先权号:   KR107307, KR111342, CN80052576

▎ 摘  要

NOVELTY - Method for producing a magnetic resonance imaging contrast agent involves (a) preparing a saccharide solution by adding carbon-13 (13C)-containing saccharides to an aqueous solution, (b) synthesizing 13C-containing graphene quantum dots by treating the saccharide solution with microwaves, and (c) preparing a magnetic resonance imaging contrast agent comprising 13C-containing graphene quantum dots. USE - The method is useful for producing magnetic resonance imaging contrast agent, which is used for obtaining and monitoring image of angiogenesis of blood vessels, lymph nodes, or cancer cells, or atherosclerosis plaques (all claimed), and diagnosing desired disease e.g. gastric cancer, lung cancer, breast cancer, liver cancer, laryngeal cancer, cervical cancer, ovarian cancer, bronchial cancer, nasopharyngeal cancer, pancreatic cancer, bladder cancer, or colon cancer. ADVANTAGE - The method is one-step method which mass-produces magnetic resonance imaging contrast agent in an easier, rapid and cost-effective manner without using harmful substances such as organic solvents, and thus avoids post-treatment process for subsequent removal. The agent has improved stability, increased solubility and low toxicity, is easily excreted from body, and reduces incidence of renal systemic fibrosis. The method enables to diagnose desired disease in a rapid and accurate manner with high sensitivity. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) magnetic resonance imaging contrast agent comprising 13C-containing graphene quantum dots as an active ingredient; and (2) method for monitoring image involves administering the magnetic resonance imaging contrast agent to the subject.