• 专利标题:   Device e.g. extracorporeal blood purification device used to treat or prevent e.g. renal failure, liver failure, rheumatoid arthritis, pancreatitis and/or sepsis, comprises cartridge or sorbent having cellular membrane derived from cell.
  • 专利号:   WO2021150460-A1, EP4093458-A1, US2023051094-A1, CN115768499-A, JP2023511333-W
  • 发明人:   GAO W
  • 专利权人:   ARYTHA BIOSCIENCES LLC, ARYTHA BIOSCIENCES LLC, ARYTHA BIOSCIENCES LLC
  • 国际专利分类:   A61M001/34, A61M001/36, B01J020/28, A61K035/14
  • 专利详细信息:   WO2021150460-A1 29 Jul 2021 A61M-001/34 202170 Pages: 41 English
  • 申请详细信息:   WO2021150460-A1 WOUS013833 18 Jan 2021
  • 优先权号:   US963465P, US17793338, CN80013335

▎ 摘  要

NOVELTY - Device e.g. an extracorporeal blood purification device, comprises a cartridge or sorbent comprising a cellular membrane derived from a cell. USE - The device is useful for: substantially removing or reducing a substance from a liquid, e.g. a subject's liquid, blood or urine, that target or attack a target cell of the subject; hemodialysis, hemofiltration, hemodiafiltration or high-flux dialysis; treating or preventing renal failure, liver failure or sepsis in a subject; treating or preventing infection, severe infection and/or sepsis in a subject, where the cellular membrane is derived from a macrophage; treating or preventing an inflammatory disorder or a severe inflammatory disorder, e.g. rheumatoid arthritis or pancreatitis in a subject, where the cellular membrane is derived from a macrophage and/or a neutrophil; treating or preventing an autoimmune disease, e.g. autoimmune anemia, in a subject, where the cellular membrane is derived from a red blood cell and/or a platelet; treating or preventing chemical or biological weapon attack in a subject, where the cellular membrane is derived from a red blood cell, a platelet and/or a neuronal cell; treating or preventing animal envenomation, e.g. fatal animal envenomation, in a subject, where the cellular membrane is derived from a red blood cell, a platelet and/or a neuronal cell; and removing or reducing multiple substances from a liquid, e.g. a subject's blood (all claimed). No biological data given. ADVANTAGE - The device: utilizes nanoparticle that is biocompatible or biodegradable; and achieves good clinical clearances for high-molecular-weight and hydrophobic molecules. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) a device assembly, comprising at least two devices, where the devices are in fluid communication and comprise cartridges or sorbents comprising cellular membranes derived from different types of cells; and (2) removing or reducing a substance from a liquid, e.g. a subject's liquid, blood or urine, comprising ex vivo, contacting a liquid, e.g. a subject's liquid, blood or urine, with a device comprising a cellular membrane derived from a cell. DESCRIPTION OF DRAWING(S) - The figure illustrates using cell membrane as the component for extracorporeal detoxification.