• 专利标题:   Cell-graphene hybrid device useful for diagnosing and treating muscle diseases in vivo and vitro, comprises a polymer support layer, a graphene layer disposed on the polymer support layer, and a cell layer disposed on the graphene layer.
  • 专利号:   KR1741189-B1
  • 发明人:   KIM D, HYEON T, CHOI S, KIM S, CHO K
  • 专利权人:   UNIV SEOUL NAT R DB FOUND, BASIC SCI INST
  • 国际专利分类:   A61B005/0492, A61N005/06, C01B031/04, C08L079/08, C08L083/04, C12N005/077
  • 专利详细信息:   KR1741189-B1 30 May 2017 A61B-005/0492 201742 Pages: 25
  • 申请详细信息:   KR1741189-B1 KR163676 21 Nov 2015
  • 优先权号:   KR163676

▎ 摘  要

NOVELTY - Cell-graphene hybrid device comprises a polymer support layer (120), a graphene layer (130) disposed on the polymer support layer, and a cell layer (150) disposed on the graphene layer. The graphene layer and the polymer support layer have serpentine shape. USE - The cell-graphene hybrid device is useful for diagnosing and treating muscle diseases in vivo and vitro. ADVANTAGE - The cell-graphene hybrid device has excellent deformability against bending, twisting and stretching,and is transparent and allows visible light to pass, and reduces side effects in vivo, and effectively monitors electrophysiological properties in vitro and vivo. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for producing cell-graphene hybrid device, comprising either: (a) transferring the graphene layer on the polymer support layer, (b) transferring the polymer support layer on a polymer substrate (110), and (c) forming the cell layer on the graphene layer, where the (a) comprises (a11) stretching the polymer substrate, (a12) placing the polymer support layer on the stretched polymer substrate, and (a13) returning the stretched polymer substrate to its original state, or (a1) transferring the graphene layer on the polymer support layer, (b1) transferring the polymer support layer on the polymer substrate, and (c1) forming the cell layer on the graphene layer, where the step (a1) comprises (a21) forming a graphene sheet on the first donor substrate, (a22) patterning the graphene sheet to form the graphene layer, (a23) forming the polymer support layer on the second donor substrate, and (a24) separating the graphene layer from the first donor substrate and placing the graphene layer on the polymer support layer. The graphene layer comprises a mesh pattern formed by the patterning. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic representation of the cell-graphene hybrid device. Cell-graphene hybrid device (100) Polymer substrate (110) Polymer support layer (120) Graphene layer (140) Cell layer (150)