• 专利标题:   Fluorinated graphene nano-drug carrier useful for preparation of drug for preventing and/or treating cancer, comprises fluorinated graphite oxidized to graphene oxide.
  • 专利号:   CN106421804-A, CN106421804-B
  • 发明人:   GONG P, DU J, JI S, LIU Z, DAI D
  • 专利权人:   UNIV QUFU NORMAL, UNIV QUFU NORMAL
  • 国际专利分类:   A61K031/519, A61K047/52, A61K047/58, A61P035/00, C01B032/184
  • 专利详细信息:   CN106421804-A 22 Feb 2017 A61K-047/52 201732 Pages: 11 Chinese
  • 申请详细信息:   CN106421804-A CN10917050 21 Oct 2016
  • 优先权号:   CN10917050

▎ 摘  要

NOVELTY - Fluorinated graphene nano-drug carrier comprises fluorinated graphite oxidized to graphene oxide. The targeting molecule is connected and modified with polyvinylpyrrolidone after carboxylation treatment. Fluorinated graphene nano-drug carrier is loaded with drug by adsorption. USE - The fluorinated graphene nano-drug carrier is useful for preparation of drug for preventing and/or treating cancer (claimed). ADVANTAGE - The carrier improves bioavailability. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for method for preparing the above-mentioned nano-drug carrier, which involves mixing fluorinated graphite with sodium hydroxide, heating the mixture using argon, reacting the mixture to obtain activated fluorinated graphite, mixing activated fluorinated graphite with concentrated sulfuric acid, stirring the mixture, adding concentrated nitric acid to the mixture, cooling the mixture, adding water to the mixture, filtering the mixture, freeze-drying the mixture to obtain fluoride oxide graphene, reacting carboxylated fluorinated graphene with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloric acid and N-hydroxysuccinimide under dark reaction, and preparing fluorinated graphene nano-drug carrier.