• 专利标题:   Method for producing a nanocomposite containing graphene oxide used in pharmaceutical composition for preparing antitumor medicament, involves diluting graphene oxide dispersions and preparing an aqueous graphene dispersion.
  • 专利号:   WO2018112575-A1, BR102016030134-A2
  • 发明人:   ALVES O L, FONSECA L C, DE ARAUJO M M, DE MORAES A C M, MARTINEZ D S T, MENEZES DE ARAUJO M, TEODORO MARTINEZ D S
  • 专利权人:   UNICAMP UNIV ESTADUAL CAMPINAS, CENT NACIONAL PESQUISA EM ENERGIA E MATE
  • 国际专利分类:   A61K009/51, A61K041/00, A61K031/70, A61P035/00, C01B032/19, C01B032/198, C01B033/141, C08K003/04, A61K009/14
  • 专利详细信息:   WO2018112575-A1 28 Jun 2018 A61K-009/51 201850 Pages: 84
  • 申请详细信息:   WO2018112575-A1 WOBR000147 18 Dec 2017
  • 优先权号:   BR10030134

▎ 摘  要

NOVELTY - Producing a nanocomposite containing graphene oxide involves diluting graphene oxide dispersions up to a concentration of 0.1-1ng/L, preparing an aqueous graphene dispersion, homogenizing surface groups for 1 hour, adding silica nanoparasite dispersion slowly to aqueous hydrochloride to obtain graphene oxide until distribution is obtained from aqueous additive oxide sheets during reaction to obtain reacted material, adding the dispersion in reacted material under stirring condition to form the separated nanocomposite, forming sheets non-covalently by washing, removing excess methyl alcohol from silica, and suspending prepared base oxide of lead. The drug is added in dispersion, encapsulated drug is separated in the nanoparticle to obtain drug-based oxide, which is further processed with N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide to obtain final product. USE - Method for producing a nanocomposite containing graphene oxide used in pharmaceutical composition for preparing antitumor, antimicrobial, anti-inflammatory, antiseptic and antimalarial medicament (claimed). ADVANTAGE - The method enables to produce a nanocomposite containing graphene oxide, which shows a decrease in level of hemolysis, shows reduced interaction with blood proteins, which include protein family of immunological system, and prevents its early elimination from circulatory system before delivering hydrophobic drug to biological target.