• 专利标题:   Preparing porous material based on enzyme catalytic crosslinking useful in tissue engineering technology, comprises e.g. mixing regenerated silk-fibroin solution with re-adding solution, adding crosslinking agent to pre-mixing solution for crosslinking.
  • 专利号:   CN116059450-A
  • 发明人:   FENG K, CAI Y, WU J, ZHANG H
  • 专利权人:   MEIDIAN BEIJING MEDICAL DEVICES CO LTD
  • 国际专利分类:   A61L027/22, A61L027/44, A61L027/52, A61L027/56
  • 专利详细信息:   CN116059450-A 05 May 2023 A61L-027/56 202349 Chinese
  • 申请详细信息:   CN116059450-A CN10356418 06 Apr 2023
  • 优先权号:   CN10356418

▎ 摘  要

NOVELTY - Method for preparing porous material based on enzyme catalytic crosslinking comprises (a) preparing regenerative silk fibroin solution and then adding solution, (b) mixing the regenerated silk- fibroin solution with the re-adding solution to obtain a pre-mixed solution, and (c) adding crosslinking agent to the pre-mixing solution for crosslinking to obtain the mixed solution, where the re-adding solution comprises graphene solution, oxidized graphene solution or porous oxidized-graphene solution. USE - The method is useful for preparing porous material based on enzyme catalytic crosslinking, which is useful in tissue engineering technology, membrane-guided tissue regeneration, gene therapy, and growth factor induction for treating bone defect. ADVANTAGE - The method provides porous material with regular pore diameter, uniform porosity, high porosity and good mechanical property and biocompatibility. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for a porous material based on enzyme catalytic crosslinking. DESCRIPTION OF DRAWING(S) - The drawing shows a flow chart illustrating the method for preparing porous material based on enzyme catalytic crosslinking (Drawing includes non-English language text).