▎ 摘　　要

NOVELTY - Optimizing the beneficial microbiome growth in the genital region of a subject in need involves applying a pharmaceutical composition having an acidic pH to the genital region of the subject or to the genital region of a sexual partner of the subject in need. USE - Method for optimizing the beneficial microbiome in the genital region of the subject in need, where composition applied to the patient is used for enhancing the genital microbiota of a subject by increasing the colony count of beneficial genital microbiota of a subject, enhancing gamete function of a subject, reducing sexually transmitted disease incidence, penile cancer persistence or occurrence, or urethritis, or increasing or maintaining sperm quality. ADVANTAGE - The method is involved in using a pharmaceutical composition for urogenital, anogenital, vaginal or penile use and are not harmful to the genital tissues, to modulate the genital microbiome, may require distinct prebiotic or probiotic constituents and preserve and support the beneficial regional microbiome of these areas. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a system for the measurement of one or more parameters of the metabolomic profile of a biological sample ( e.g., derived from saliva, blood, urine, feces, genital fluids, tears, nasal swabs, sweat, psoriasis lesions), which comprises a substrate, a sensor medium immobilized on substrate comprising a microfluidic chip or multiple carbon nanostructures, where multiple carbon nanostructures have one or more conductive materials deposited, two conductive terminals in electrical connection with the sensor medium and spaced from each other, measurement system to measure one or more electrical properties of the sensor medium when the sensor medium comprises the biological sample deposited, and a correlation system calibrated to correlate the measured electrical property with the one or more parameters of the metabolomic profile of the biological sample; (2) a method for the measurement of one or more parameters of the metabolomic profile of a biological sample (e.g., derived from saliva, blood, urine, feces, genital fluids, tears, nasal swabs, sweat, psoriasis lesions), which involves depositing the biological sample on a sensor medium comprising multiple carbon nanostructures, where multiple carbon nanostructures has one or more conductive materials deposited, measuring an electrical property of the sensor medium after depositing the biological sample, and correlating the measured electrical property to the one or more parameters of the metabolomic profile; (3) a method of optimizing the beneficial microbiome growth in the genital region of a subject in need, which involves measuring parameters of the metabolomic profile of a biological sample with the system, applying a pharmaceutical composition having an acidic pH to the genital region of the subject or to the genital region of a sexual partner of the subject in need thereof based on the one or more parameters of the metabolomic profile; (4) a device for the measurement of one or more parameters of the metabolomic profile of a biological sample ( e.g., derived from saliva, blood, urine, feces, genital fluids, tears, nasal swabs, sweat, psoriasis lesions), which comprises a handle portion dimensioned to be held in a user s hand comprising a power source (e.g., batteries such as a lithium ion battery, solar cells), and a sensor portion comprising sensors, where the sensors comprise: a substrate, a sensor medium immobilized on substrate comprising multiple carbon nanostructures, where multiple carbon nanostructures has conductive materials deposited, two conductive terminals in electrical connection with the sensor medium and spaced from each other, where sensor portion is removably attached to the handle portion, and when the sensor portion is attached to the handle portion, the systems are in electrical communication with the power source, and device comprises measurement system to measure one or more electrical properties of the sensor medium when the sensor medium comprises the biological sample deposited; (5) a kit, which comprises an upper waste receptacle (a), and a lower portion comprising two dispensing compartments (c and d), where kit is configured to hold a supply of applicators for treatment with a gel composition of about one month or greater, where waste receptacle is configured to hold or safely contain waste products from treatment and whose one side has punch open flap (b), and where kit is composed of one or more degradable materials that can be safely disposed of by burning, incineration, or recycling; and (6) a pharmaceutical composition, which comprises a metallic co-factor ( e.g., manganese chloride), a prebiotic oligosaccharide (e.g., lactulose), borneol or a prodrug (e.g., bomyl acetate), where composition is buffered with a buffer system comprising gluconolactone. DESCRIPTION OF DRAWING(S) - The drawing shows the schematic view of the kit. Upper waste receptacle (a) Punch open flap (b) Two dispensing compartments (c and d)