• 专利标题:   Preparing injectable temperature-sensitive hydrogel for repairing myocardial infarction, by dissolving polyether F127 diacrylate, adding vitamin E, ultrasonicating, and adding conductive substance, amino acid modified dopamine and photoinitiator and irradiating material.
  • 专利号:   CN115957181-A
  • 发明人:   CUI C
  • 专利权人:   JIANGSU PROVINCE HOSPITAL
  • 国际专利分类:   A61K031/355, A61K047/34, A61K047/42, A61K050/00, A61K009/06, A61P009/10
  • 专利详细信息:   CN115957181-A 14 Apr 2023 A61K-009/06 202342 Chinese
  • 申请详细信息:   CN115957181-A CN10079529 08 Feb 2023
  • 优先权号:   CN10079529

▎ 摘  要

NOVELTY - A method for preparing injectable temperature-sensitive hydrogel involves (S1) dissolving polyether F127 diacrylate in water to form a micelle structure, and generating an internal hydrophobic core and an external hydrophilic shell, (S2) adding fat-soluble vitamin E or its derivatives, performing ultrasonic treatment after vortexing, and stirring uniformly to ensure that the micelle core fully loads the vitamin E or its derivatives, (S3) adding a conductive substance, and uniformly dispersing to enhance the conductivity of the material, (S4) adding arginine-glycine-aspartic acid modified dopamine to respectively enhance adhesion and biocompatibility of the material, and (S5) adding dissolved photoinitiator lithium phenyl (2,4,6-trimethylbenzoyl) phosphinate (LAP) to improve stability of the material, and irradiating the material with preset wavelength light to form a gel after uniformly stirring. USE - The injectable temperature-sensitive hydrogel is useful for repairing myocardial infarction (claimed). ADVANTAGE - The material is quickly gelatinized and attached to surface of the tissue in body temperature environment when injected into the myocardial infarction area. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a hydrogel synthesized by the above method.