• 专利标题:   Durable graphene antiviral and antibacterial liquid comprises graphene oxide, antibacterial synergistic agent, sodium dodecylbenzenesulfonate, sorbitan monooleate, glycerol, propylene glycol and water.
  • 专利号:   CN113767929-A
  • 发明人:   MA Y, WANG Y, SUN X
  • 专利权人:   SUN X
  • 国际专利分类:   A01N043/78, A01N059/00, A01P001/00, A01P003/00, C07D277/56
  • 专利详细信息:   CN113767929-A 10 Dec 2021 A01N-059/00 202227 Chinese
  • 申请详细信息:   CN113767929-A CN11191898 13 Oct 2021
  • 优先权号:   CN11191898

▎ 摘  要

NOVELTY - Durable graphene antiviral and antibacterial liquid comprises 3-8 pts. wt. graphene oxide, 10-15 pts. wt. antibacterial synergistic agent, 3.5-5 pts. wt. sodium dodecylbenzenesulfonate, 3-5 pts. wt. emulsifier, 1-3 pts. wt. glycerol, 1-3 pts. wt. propylene glycol and 80-100 pts. wt. water. USE - Used as durable graphene antiviral and antibacterial liquid. ADVANTAGE - The liquid causes bacterial cell death, blocks electron transfer between cytochrome b and cytochrome c1 thus inhibiting mitochondrial respiration, and makes mitochondria unable to supply the energy needed for normal metabolism of cells. DETAILED DESCRIPTION - Durable graphene antiviral and antibacterial liquid comprises 3-8 pts. wt. graphene oxide, 10-15 pts. wt. antibacterial synergistic agent, 3.5-5 pts. wt. sodium dodecylbenzenesulfonate, 3-5 pts. wt. emulsifier, 1-3 pts. wt. glycerol, 1-3 pts. wt. propylene glycol and 80-100 pts. wt. water. The preparation of antibacterial synergistic agent comprises (a) adding 2-amino-4-nitrotoluene, deionized water and concentrated hydrochloric acid into a reaction kettle, stirring, cooling, adding sodium nitrite solution, reacting, adjusting pH of the reaction liquid to 5 to obtain intermediate I, adding deionized water, copper sulfate pentahydrate and acetic acid into the reaction kettle, stirring, adding acetaldoxime and sodium sulfite, adjusting pH to 7, cooling, adding intermediate I, and reacting to obtain intermediate II; (b) adding intermediate II, deionized water and concentrated hydrochloric acid into reaction kettle, and reflowing to obtain intermediate III, adding intermediate III, potassium hydroxide and deionized water into the reaction kettle, stirring, adding potassium permanganate and reacting to obtain intermediate IV, adding intermediate IV, concentrated sulfuric acid and methanol into the reaction kettle, performing reflux reaction for 3-5 hours to obtain intermediate V, adding intermediate V, methoxyamine hydrochloride and ethanol into the reaction kettle, performing reflux reaction to obtain intermediate VI, adding intermediate VI, carbon tetrachloride, benzoyl peroxide and N-Bromosuccinimide into the reaction kettle, and performing reflux reaction to obtain intermediate VII; (c) adding methylbenzyl chloride, sodium cyanide, ethanol and dimethylamine into reaction kettle, performing reflux reaction to obtain intermediate VIII, adding intermediate VIII, phosphorus pentasulfide and anhydrous sodium sulfite into the reaction kettle, stirring, adding deionized water, and continuously stirring to obtain intermediate IX, intermediate IX, acetonitrile, ethyl 2-chloro-4,4,4-trifluoroacetoacetate into the reaction kettle, stirring, adding triethylamine and performing reflux reaction to obtain intermediate X, mixing intermediate X and sodium hydroxide solution, performing reflux reaction, adjusting pH of the reaction solution to obtain intermediate XI; and (d) adding intermediate VII, tin powder and concentrated hydrochloric acid into the reaction kettle, reacting, adjusting the pH of the reaction liquid to obtain intermediate XII, adding intermediate XI, thionyl chloride, N,N-dimethyl formamide into the reaction kettle, refluxing, removing solvent, adding xylene and intermediate 12, carrying out reflux reaction to obtain intermediate XIII, adding intermediate XIII, dimethylaminoethanol and sodium acetate into the reaction kettle, and reacting to obtain intermediate XIV, adding intermediate XIV, acetonitrile and hydroquinone into the reaction kettle, stirring, adding bromohexadecane, and reacting. An INDEPENDENT CLAIM is also included for preparing the antiviral and antibacterial liquid, comprising (i) adding graphene oxide, sodium dodecylbenzenesulfonate and water into a reaction kettle, and stirring at 600-800 revolutions/minute for 20-30 minutes to obtain dispersion; and (ii) adding dispersion, antibacterial synergistic agent, emulsifier, glycerol and propylene glycol into the reaction kettle, and stirring at 1000-1200 revolutions/minute for 1-1.5 hours.