▎ 摘　　要

NOVELTY - Preparation of drug delivery system involves adding hyaluronic acid, N-hydroxysuccinimide, phosphate-buffered saline buffer solution and carbodiimide to a reactor and then mixing, adding amine-polyethylene glycol and phosphate-buffered saline buffer solution to the mixture and then reacting, adding graphene oxide, 2-(N-morpholino)ethanesulfonic acid buffer solution, N-hydroxysuccinimide, carbodiimide and chitosan solution to the mixture and then processing, adding anti-tumor medicine and phosphate-buffered saline buffer solution to the mixture, and precipitating. USE - The method is useful for preparation of drug delivery system. ADVANTAGE - The method enables preparation of drug delivery system with excellent slow release properties, hydrophilicity, biological compatibility, dispersibility and prolonged service life. DETAILED DESCRIPTION - Preparation of drug delivery system involves adding 30 mg hyaluronic acid, 70 mg N-hydroxysuccinimide, 10 ml or 0.01 M phosphate-buffered saline buffer solution and 80 mg carbodiimide to a reactor and then mixing, adding 5 ml amine-polyethylene glycol and 0.01 M phosphate-buffered saline buffer solution to the mixture and then reacting, adding 10-50 mg graphene oxide, 10 ml or 0.01 M 2-(N-morpholino)ethanesulfonic acid buffer solution, 80 mg N-hydroxysuccinimide, 100 mg carbodiimide and 5-10 ml or 5 mg/ml chitosan solution to the mixture and then ultrasonically processing for 10 minutes, filtering the mixture using 0.01 M phosphate-buffered saline buffer solution, adding 50-200 mg anti-tumor medicine and 5 ml phosphate-buffered saline buffer solution to the filtrate and then centrifuging, and precipitating. An INDEPENDENT CLAIM is included for drug delivery system prepared by the method.