• 专利标题:   Nanocomposite delivery system useful for cancer treatment, comprises graphene composite including graphene oxide including carboxy group, cancer targeting ligand bound to the graphene oxide, and photosensitizer.
  • 专利号:   KR2023023391-A
  • 发明人:   KIM S Y, HWA L S
  • 专利权人:   UNIV IND ACADEMIC COOP IN CHUNGNAM NAT
  • 国际专利分类:   A61K041/00, A61K049/22, A61K009/51, A61P035/00
  • 专利详细信息:   KR2023023391-A 17 Feb 2023 A61K-041/00 202319 Pages: 35
  • 申请详细信息:   KR2023023391-A KR105490 10 Aug 2021
  • 优先权号:   KR105490

▎ 摘  要

NOVELTY - Nanocomposite delivery system comprises: a graphene composite including graphene oxide including a carboxy group, a cancer targeting ligand bound to the graphene oxide, and a photosensitizer bound to the graphene oxide; and metal photothermal particles bound to the graphene composite. USE - The nanocomposite delivery system is useful for cancer treatment (claimed). ADVANTAGE - The nanocomposite delivery system: has excellent reactive oxygen species generating ability, photothermal conversion ability and excellent photodynamic/photothermal therapeutic effect; achieves excellent therapeutic effects even when administered in small amounts; and is capable of rapidly diagnosing cancer through photoacoustic images through photothermal conversion of thermal energy. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for manufacturing nanocomposite delivery system, comprising (a) preparing a reduced graphene oxide in which a carboxy group is located in edge region by partially reducing the graphene oxide, (b) obtaining a graphene composite by covalently bonding the reduced graphene oxide with a polymer including a cancer-targeting ligand and a compound including a photosensitizer, and (c) mixing metal photothermal particles with the graphene composite.