• 专利标题:   Surface-enhanced Raman spectroscopy virus detection chip for detecting coronavirus, comprises SERS substrate, graphene arranged on SERS substrate, and angiotensin-converting enzyme 2 biological probe arranged on graphene and SERS substrate includes silicon/silica wafer as base.
  • 专利号:   CN114544594-A
  • 发明人:   QIN Z, LIU T, GAO X, CHANG H, LI H, QIN M, FAN X, CHEN H, WEI Q, WANG X, JIA X, ZHOU J, DENG J, LIU Y, WANG G
  • 专利权人:   UNIV GUANGXI SCI TECHNOLOGY
  • 国际专利分类:   B82Y030/00, C12Q001/70, C12R001/93, G01N021/65, G01N033/569
  • 专利详细信息:   CN114544594-A 27 May 2022 G01N-021/65 202272 Chinese
  • 申请详细信息:   CN114544594-A CN10307526 25 Mar 2022
  • 优先权号:   CN10307526

▎ 摘  要

NOVELTY - Surface-enhanced Raman spectroscopy (SERS) virus detection chip comprises a SERS substrate, a graphene (3) arranged on the SERS substrate, and an angiotensin-converting enzyme 2 (ACE2) biological probe (4) arranged on the graphene. The SERS substrate includes a silicon (Si)/ silica (SiO2) wafer (1) as a base and metal nanostructures (2) above it. USE - Surface-enhanced Raman spectroscopy (SERS) virus detection chip for detecting coronavirus. ADVANTAGE - The surface-enhanced Raman spectroscopy virus detection chip achieves high-sensitivity detection of coronaviruses with fast and efficient, and higher capture efficiency. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparing SERS virus detection chip, which involves preparing metal nanostructures on Si/SiO2 wafers to form SERS substrates, transferring the single-layer CVD graphene to the SERS substrate, modifying ACE2 on graphene to form a crown detection probe, and completing preparation of SERS virus detection chip. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of surface-enhanced Raman spectroscopy virus detection chip. 1Silicon/silica wafer 2metal nanostructures 3Graphene 4Angiotensin-converting enzyme 2 biological probe