▎ 摘　　要

NOVELTY - Method for three-dimensional printing functional hydrogel wound dressing comprises e.g. (1) preparing printing ink containing 0-3 wt.% TO-cellulose nano fiber, 5-30 wt.% gelatin methacryloyl, and 0.5 wt.% photoinitiator, (2) screening printing parameters of ink, determining printable ink density and printing parameters, (3) joining gelatin methacryloyl-dopamine in printable ink, preparing composite ink containing 5-20% gelatin methacryloyl-dopamine, (4) adding polydopamine-reduced graphene oxide to composite ink, controlling content of polydopamine-reduced graphene oxide to 0-8 mg/ml, (5) passing composite ink into a syringe, centrifugally defoaming, and pre-cooling in refrigerator, and (6) placing syringe containing the pre-cooled composite ink into extrusion three-dimensional printer, carrying out three-dimentional printing of the composite hydrogel using printable ink concentration determined and the printing speed and extrusion pressure. USE - The method is useful for preparing three-dimensional printing functional hydrogel wound dressing, which is useful in field of biological material. ADVANTAGE - The hydrogel has good photo-thermal antibacterial performance, conductivity, hemostasis and biological degradability, capable of maintaining wound wet and promoting wound healing function. DETAILED DESCRIPTION - Method for three-dimensional printing functional hydrogel wound dressing comprises (1) preparing printing ink containing 0-3 wt.% TO-cellulose nano fiber, 5-30 wt.% gelatin methacryloyl, and 0.5 wt.% photoinitiator, (2) screening printing parameters of ink, determining printable ink density and printing parameters, (3) joining gelatin methacryloyl-dopamine in printable ink, preparing composite ink containing 5-20% gelatin methacryloyl-dopamine, (4) adding polydopamine-reduced graphene oxide to composite ink, controlling content of polydopamine-reduced graphene oxide to 0-8 mg/ml, (5) passing composite ink into a syringe, centrifugally defoaming, and pre-cooling in refrigerator, (6) placing syringe containing the precooled composite ink into extrusion three-dimensional printer, carrying out three-dimensional printing of the composite hydrogel using printable ink concentration determined and the printing speed and extrusion pressure, (7) carrying out UV crosslinking and calcium ion complexation crosslinking to hydrogel printed, and (8) performing photothermal antibacterial on crosslinked wound dressing.