• 专利标题:   Fabrication of electrically conductive aligned nanofibrous scaffold by dissolving chitosan and gelatin in solvent mixture, adding polyvinyl alcohol to chitosan-gelatin solution, adding reduced graphene oxide to spinning solution, electrospinning solution, and crosslinking electrospun nanofibers.
  • 专利号:   IN202211058482-A
  • 发明人:   KUMAR A, SRIVASTAVA E
  • 专利权人:   INDIAN INST TECHNOLOGY KANPUR
  • 国际专利分类:   A61L027/38, B01D071/10, B33Y080/00, D01F006/18, D04H001/728
  • 专利详细信息:   IN202211058482-A 21 Oct 2022 A61L-027/38 202301 Pages: 47 English
  • 申请详细信息:   IN202211058482-A IN11058482 13 Oct 2022
  • 优先权号:   IN11058482

▎ 摘  要

NOVELTY - Process for fabrication of an electrically conductive aligned nanofibrous scaffold, involves (a) dissolving chitosan and gelatin in a solvent mixture to obtain a chitosan-gelatin solution, (b) adding 2 wt.% polyvinyl alcohol to the chitosan-gelatin solution to obtain a first spinning solution, and adding 0.5wt.%/vol.% reduced graphene oxide to the first spinning solution to obtain a second spinning solution, (c) electrospinning the second spinning solution to obtain an electrospun nanofibers, and (d) crosslinking the electrospun nanofibers with glutaraldehyde vapors to obtain the electrically conductive aligned nanofibrous scaffold. USE - The process is useful for fabrication of an electrically conductive aligned nanofibrous scaffold. ADVANTAGE - The prepared scaffold is configured to have structurally stable and aligned nanofibers matching young modulus of a native nervous tissue.