• 专利标题:   Preparation of composite multilayer on surface of medical magnesium alloy used in vascular stent implantable medical device, involves immersing surface modified magnesium alloy with heparin modified graphene oxide and chitosan solution.
  • 专利号:   CN107137788-A, WO2018196088-A1, CN107137788-B
  • 发明人:   PAN C, LIU T, GONG T, ZHANG L, YE W
  • 专利权人:   HUAIYIN TECHNOLOGY INST, HUAIYIN TECHNOLOGY INST
  • 国际专利分类:   A61L031/08, A61L031/10, A61L031/12, A61L031/14, A61L031/16
  • 专利详细信息:   CN107137788-A 08 Sep 2017 A61L-031/12 201776 Pages: 8 Chinese
  • 申请详细信息:   CN107137788-A CN10297089 28 Apr 2017
  • 优先权号:   CN10297089

▎ 摘  要

NOVELTY - Preparation of chitosan/heparin modified graphene oxide composite multilayer on surface of medical magnesium alloy involves preparing negatively charged heparin modified graphene oxide, subjecting the magnesium alloy surface to chemical treatment and self-assembly surface modification, carrying out covalent immobilization of chitosan on the surface of the magnesium alloy for constructing positively charged material, immersing the resultant alloy with heparin modified graphene oxide solution and chitosan solution and drying. USE - Preparation of composite multilayer on surface of medical magnesium alloy used in vascular stent implantable medical device. ADVANTAGE - The method provides magnesium alloy with improved corrosion resistance and biocompatibility.