• 专利标题:   Hemostatic hydrogel useful e.g. in substantive organs and treating multi-drug-resistant bacterial infection comprises aldehyde compound, methacrylamide compound, photoinitiator, and water.
  • 专利号:   CN115671371-A
  • 发明人:   GAO W, SUN D, LI T
  • 专利权人:   TIANJIN THIRD CENT HOSPITAL
  • 国际专利分类:   A61L024/00, A61L024/08, C08J003/075, C08J003/24, C08L005/08, C08L005/16
  • 专利详细信息:   CN115671371-A 03 Feb 2023 A61L-024/08 202319 Chinese
  • 申请详细信息:   CN115671371-A CN10843773 26 Jul 2021
  • 优先权号:   CN10843773

▎ 摘  要

NOVELTY - Hemostatic hydrogel comprises 1-20 wt.% aldehyde compound, 10-30% methacrylamide compound, 0.1-2% photoinitiator and water (remaining amount). USE - The hemostatic hydrogel is useful in substantive organs. The solid organs include heart, liver, spleen, lung, kidney, tissue engineering of skin (all claimed), and treating multi-drug-resistant bacterial infection and full-layer skin incision/defect repair. ADVANTAGE - The hemostatic hydrogel has viscoelasticity and fluidity, can be injected into the bleeding part tissue to the irregular wound tissue, forming solid gel has the effect of fast hemostasis, and has firm tissue adhesion, can locally remain in the body for one month, bleeding part after operation can be well healed, and the material has good biocompatibility, no inflammation reaction. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparing the hemostatic hydrogel, comprising (i) dissolving the aldehyde compound in water to obtain solution S1; (ii) dissolving the methacrylamide compound and photoinitiator in water to obtain solution S2; and (iii) mixing solution S1 and the solution S2 under the action of ultraviolet light, and carrying out cross-linking reaction. DESCRIPTION OF DRAWING(S) - The drawing shows the actual use condition of the hemostatic hydrogel of the invention in the rat heart.