▎ 摘　　要

NOVELTY - An electrochemical sensing magnetic resonance contrast agent comprises functionalized graphene material and magnetic nanoparticle. The functionalized graphene material has lamellar sheet having thickness of 1-2 nm. The magnetic nanoparticle is uniformly coated on the functionalized graphene material and has grain diameter of 10-20 nm. USE - Electrochemical sensing magnetic resonance contrast agent. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of the magnetic resonance contrast agent, comprising: (A) adding graphite powder and chitosan solid into a ball milling tank at weight ratio of 1:20-1:40 and ball milling at 500 revolutions/minute for 10-12 hours to obtain functionalized graphene material; (B) putting functionalized graphene material into a plasma device, contacting functionalized graphene material with carboxylic acid to obtain carboxyl modified functionalized graphene material; (C) ultrasonically dispersing 10 mg carboxyl modified functionalized graphene to 20 ml water, then adding aqueous solution of magnetic nanoparticle containing divalent iron ion and trivalent iron ion, stirring and mixing for 12 hours at 80 degrees C, adding 2.5-3 ml of 3 mol/L sodium hydroxide or ammonium hydroxide alkaline solution and stirring for 2-3 hours to obtain magnetic nanoparticle modified functionalized graphene composite material; and (D) spin-coating 0.1-1 ml composite material on indium tin oxide (ITO) glass electrode, and then soaking the coated ITO glass electrode into glucose oxidase solution for 5-12 hours to obtain the magnetic resonance contrast agent.