1. 平台首页
  2. 国际专利信息
  • 专利标题:   Electron microscopy support, useful for receiving biological sample e.g. serum, plasma and saliva, comprises support member, and partially hydrogenated graphene attached to member, where member is attached to support film.
  • 专利号:   WO2015022500-A1, CA2919271-A1, AU2014307798-A1, KR2016034949-A, SG11201600756-A1, EP3033303-A1, CN105658574-A, US2016203942-A1, JP2016534508-W, HK1225005-A0, IL243747-A1, US9947505-B2, AU2014307798-B2, AU2018203346-A1, SG11201600756-B, JP6434978-B2, SG10201807763-A1, SG10201807764-A1, CN109437171-A, JP2019069890-A
  • 发明人:   RUSSO C J, PASSMORE L A, RUSSO C, PASSMORE L
  • 专利权人:   MEDICAL RES COUNCIL, MEDICAL RES COUNCIL, MEDICAL RES COUNCIL, UK RES INNOVATION, MEDICAL RES COUNCIL
  • 国际专利分类:   C01B031/04, H01J037/20, B01J019/08, G01N023/04, B08B007/00, G01N033/543, H01J037/26, C01B031/02, C12M001/40, C12Q001/00, C01B000/00, H01J000/00, C01B032/182, C01B032/194, C01B032/196, G01N023/20, C01B032/198, G01N023/20025, C01B032/186, G01N001/00, H05H001/24
  • 专利详细信息:   WO2015022500-A1 19 Feb 2015 C01B-031/04 201517 Pages: 67 English
  • 申请详细信息:   WO2015022500-A1 WOGB052423 07 Aug 2014
  • 优先权号:   US865359P, GB018463, AU307798, CA2919271, AU203346

▎ 摘　　要

NOVELTY - The electron microscopy support comprises a support member, a partially hydrogenated graphene attached to the support member, and a biological molecule adsorbed to the partially hydrogenated graphene. The graphene is 5% hydrogenated graphene. The support member is attached to a support film comprising carbon, and the graphene is attached to the support film. The partially hydrogenated graphene comprises a first area of graphene and a further area of graphene, where the first area is hydrogenated to a first hydrogenation value. USE - The electron microscopy support is useful for receiving a biological sample and in a sensor and an imaging apparatus operable to provide an electron microscopy image of a biological sample (all claimed), where the sample comprises fluid such as body fluid comprising blood, serum, plasma, cerebrospinal fluid, saliva, semen or urine, whole organisms such as bacteria or viruses and biological molecule extracted or purified from an organism. ADVANTAGE - The electron microscopy support improves sample preparation and image quality in biological electron microscopy, has improved mechanical strength/stability, enables robotic handling and/or robotic sample preparation for electron microscopy, and is free from silicone. DETAILED DESCRIPTION - The electron microscopy support comprises a support member, a partially hydrogenated graphene attached to the support member, and a biological molecule adsorbed to the partially hydrogenated graphene. The graphene is 5% hydrogenated graphene. The support member is attached to a support film comprising carbon, and the graphene is attached to the support film. The partially hydrogenated graphene comprises a first area of graphene and a further area of graphene, where the first area is hydrogenated to a first hydrogenation value and the further area is hydrogenated to a different hydrogenation value. The graphene is prepared using a hydrogen plasma at an energy of 1-14 eV. INDEPENDENT CLAIMS are included for: (1) a method for making a partially hydrogenated graphene; (2) a partially hydrogenated graphene; (3) a sensor comprising a surface capable of adsorbing a biological molecule; (4) a method for cleaning a graphene surface; (5) a cleaned graphene; (6) a method of imaging a biological sample; and (7) an imaging apparatus operable to provide an electron microscopy image of a biological sample.