▎ 摘　　要

NOVELTY - Preparing a medical metal surface slow-released growth factor coating, involves using graphene oxide as the growth factor carrier, dissolving growth factors in composite nano-granules formed by polycations and polyanions, reacting the nano-granules containing the growth factors with the carboxylated graphene oxide to form amido bonds, fixing the nano-granules on the graphene oxide, and enabling the graphene oxide to form the coating. USE - The method is useful for preparing a medical metal surface slow-released growth factor coating (claimed). ADVANTAGE - The method enables to realize higher growth factor carrying quantity, and protects the activity of the growth factors. DETAILED DESCRIPTION - Method of preparing a medical metal surface slow-released growth factor coating, involves using graphene oxide as the growth factor carrier, dissolving growth factors in composite nano-granules formed by polycations and polyanions (1:2-5) containing solution (0.5-2.5 mg/ml), reacting the nano-granules containing the growth factors with the carboxylated graphene oxide to form amido bonds, fixing the nano-granules on the graphene oxide, and enabling the graphene oxide carrying the growth factors to form the coating on a biologic medical metal surface which is subjected to dopamine treatment by using an extraction method.