• 专利标题:   Preparing favilavir molecularly imprinted paste electrode sensor comprises e.g. preparing gallium phosphide/quantum dot paste electrode by grinding nano phosphide gallium, graphene oxide and 1-ethyl methyl ether-3-methyl imidazole phosphate.
  • 专利号:   CN111551617-A
  • 发明人:   LI H, XU C, ZHU X
  • 专利权人:   UNIV JINAN
  • 国际专利分类:   B82Y015/00, G01N027/30, G01N027/48
  • 专利详细信息:   CN111551617-A 18 Aug 2020 G01N-027/48 202073 Pages: 7 Chinese
  • 申请详细信息:   CN111551617-A CN10271985 09 Apr 2020
  • 优先权号:   CN10271985

▎ 摘  要

NOVELTY - Preparing favilavir molecularly imprinted paste electrode sensor, comprises (i) preparing gallium phosphide/quantum dot paste electrode; (ii) preparing gamma -glycidyl ether oxypropyl trimethoxysilane modified gallium phosphide/quantum dot paste electrode; (iii) dissolving ethanol, 8-12 wt.% tetraethylenepentamine, 6-10 wt.% 2-aminopyrrole, 4-8 wt.% favilavir, 4-8 wt.% trimethylolpropane triglycidyl ether and 1-3 wt.% azobisisoheptanonitrile by stirring, deoxidizing with argon for 15 minutes, placing in anaerobic atmosphere at 55 plus minus 2 degrees C, stirring and reacting for 2-4 hours, performing solid-liquid separation, soaking in a mixed solution of alcohol and acetic acid in volume ratio of 8:1 for 8 hours, washing repeatedly, removing template molecules, and drying; and (iv) adding favilavir molecularly imprinted polymer modification solution dropwise into gamma -glycidoxypropyltrimethoxysilane modified gallium phosphide/quantum dot paste electrode and evaporating the dry solvent. USE - The method is useful for preparing favilavir molecularly imprinted paste electrode sensor. ADVANTAGE - The sensor prepared has high sensitivity, good specificity, rapid detection, and can be used repeatedly. DETAILED DESCRIPTION - Preparing favilavir molecularly imprinted paste electrode sensor, comprises (i) adding 44-48 wt.% nano phosphide gallium, 16-20 wt.% graphene oxide, 12-16 wt.% 1-ethyl methyl ether-3-methyl imidazole phosphate, 4-6 wt.% carbon quantum dots, 8-12 wt.% glycerol and 6-10 wt.% ethanol into an agate mortar, uniformly grinding, placing carbon paste into a glass tube with an inner diameter of phi 5 mm connected with a wire, compacting, drying, grinding with a polishing powder, polishing, and washing with deionized water to obtain gallium phosphide/quantum dot paste electrode; (ii) stirring 70-74 wt.% ethanol and 26-30 wt.% gamma -glycidoxypropyl trimethoxysilane in reactor to dissolve, soaking in polished gallium nitride paste electrode for 4 hours at room temperature, reacting at constant temperature to 55 plus minus 2 degrees C for 4 hours, washing with absolute ethanol and drying to obtain gamma -glycidyl ether oxypropyl trimethoxysilane modified gallium phosphide/quantum dot paste electrode; (iii) dissolving 66-72 wt.% ethanol, 8-12 wt.% tetraethylenepentamine, 6-10 wt.% 2-aminopyrrole, 4-8 wt.% favilavir, 4-8 wt.% trimethylolpropane triglycidyl ether and 1-3 wt.% azobisisoheptanonitrile by stirring, deoxidizing with argon for 15 minutes, placing in anaerobic atmosphere at 55 plus minus 2 degrees C, stirring and reacting for 2-4 hours, performing solid-liquid separation, soaking in a mixed solution of alcohol and acetic acid in volume ratio of 8:1 for 8 hours, washing repeatedly, removing template molecules, and drying to obtain favilavir molecularly imprinted polymer; and (iv) dissolving 95-97 wt.% N,N-dimethylformamide, 1-3 wt.% vinyl resin and 1-3 wt.% favilavir molecularly imprinted polymer by heating, adding 20-30 mu l favilavir molecularly imprinted polymer modification solution dropwise into gamma -glycidoxypropyltrimethoxysilane modified gallium phosphide/quantum dot paste electrode, placing under an infrared lamp and evaporating the dry solvent. An INDEPENDENT CLAIM is also included for favilavir molecularly imprinted paste electrode sensor, prepared as mentioned above.