• 专利标题:   Wirelessly-powered contact lens useful for monitoring intraocular pressure and treating glaucoma, comprises transparent strain sensor capable of measuring intraocular pressure of subject, and drug reservoir.
  • 专利号:   WO2022050451-A1, US2023190523-A1
  • 发明人:   HAHN S K, SHIN S B, KIM T Y
  • 专利权人:   PHI BIOMED INC, POSTECH ACADIND FOUND, POSTECH ACADIND FOUND, PHI BIOMED INC
  • 国际专利分类:   A61B003/125, A61B003/16, A61B005/00, A61B005/022, A61F009/00, A61K009/00, G02C007/04, A61K031/5377, A61K031/5575
  • 专利详细信息:   WO2022050451-A1 10 Mar 2022 202225 Pages: 31
  • 申请详细信息:   WO2022050451-A1 WOKR011909 04 Sep 2020
  • 优先权号:   WOKR011909, US17610682

▎ 摘  要

NOVELTY - Wirelessly-powered contact lens comprises a transparent strain sensor capable of measuring intraocular pressure of a subject, and a drug reservoir. The strain sensor and drug reservoir are formed on a transparent substrate, and the strain sensor measures a change in resistance due to a change in intraocular pressure, where a drug is released from the drug reservoir when an abnormality is detected in the change in intraocular pressure. USE - The wirelessly driven contact lens is useful for monitoring intraocular pressure and treating glaucoma in a glaucoma patient (all claimed). ADVANTAGE - The wirelessly driven contact lens ensures monitoring of intraocular pressure in an accurate manner with high sensitivity, prevents loss of therapeutic drugs by using flexible drug reservoir, does not obstruct patient's field of vision by using transparent strain sensor, can minimize side effects of drugs and maximize effect of treating glaucoma. The system can communicate non-invasively and conveniently through smart glasses capable of wireless communication with the outside. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) method for producing the wirelessly driven contact lens for monitoring intraocular pressure and treating glaucoma of a glaucoma patient, involves forming a sacrificial layer soluble in water on the handling substrate, forming a transparent substrate on the sacrificial layer, forming strain sensor and drug reservoir on the transparent substrate, and transferring the transparent substrate on which the strain sensor and drug reservoir are formed into a contact lens; (2) system comprising transparent strain sensor that measures intraocular pressure of the subject, and a radio-actuated contact lens comprising a drug reservoir, and smart glasses that wirelessly transmit or receive electrical signals to control operation of the strain sensor and drug reservoir of wirelessly driven contact lens; and (3) method for treating glaucoma involves applying a constant voltage to eye of subject at a predetermined measurement time by strain sensor in contact lens to wirelessly measure change in current according to change in resistance, where the drug reservoir is opened as gold of the electrode pattern sealing the drug well of the drug reservoir is dissolved in chlorine ions to become tetrachloroaurate ion.