• 专利标题:   Soft tissue repair patch material used in biological tissue engineering, comprises sodium alginate/graphene hydrogel comprising sodium alginate, gelatin, graphene and first solvent, and fibrin/graphene hydrogel comprising fibrin, gelatin, graphene, hyaluronic acid, glycerol and a second solvent.
  • 专利号:   CN113663124-A, CN113663124-B
  • 发明人:   WANG L, ZHAO W, FU Q, LI W, YANG X, NIU C, ZHANG K
  • 专利权人:   SUZHOU NUOPU REGENERATIVE MEDICINE CO
  • 国际专利分类:   A61F002/00, A61L027/08, A61L027/20, A61L027/22, A61L027/38, A61L027/50, A61L027/52, A61L027/58, B33Y080/00
  • 专利详细信息:   CN113663124-A 19 Nov 2021 A61L-027/08 202238 Chinese
  • 申请详细信息:   CN113663124-A CN10414073 15 May 2020
  • 优先权号:   CN10414073

▎ 摘  要

NOVELTY - The soft tissue repair patch material comprises sodium alginate/graphene hydrogel, and fibrin/graphene hydrogel in a mass ratio of (1-10): 1. The sodium alginate/graphene hydrogel comprises sodium alginate, gelatin, graphene and a first solvent in a mass ratio of (10-30): (10-30): (0.01-0.3): 1000, preferably (11-28): (11-28): (0.1-0.3): 1000. The fibrin/graphene hydrogel comprises fibrin, gelatin, graphene, hyaluronic acid, glycerol and a second solvent in a mass ratio of (10-30): (25-45): (0.01-0.3): (1-5): (50-150): 1000, preferably (11-28): (26-44): (0.01-0.1): (1.2-4.8): (75-130): 1000. The first and second solvent are a phosphate buffered saline solution. USE - Soft tissue repair patch material used in biological tissue engineering (claimed). ADVANTAGE - The sodium alginate/graphene hydrogel has certain mechanical strength and relatively low degradation rate, and can make up the defects of insufficient mechanical property and excessively high degradation rate of the fibrin/graphene hydrogel, so that sufficient mechanical support and tissue repair time are provided for the prepared soft tissue repair patch. The fibrin/graphene hydrogel has good biocompatibility, is beneficial to large-scale cell amplification and propagation and promotes soft tissue repair, and the two hydrogel systems are cooperatively used, so that the soft tissue repair patch prepared by adopting the soft tissue repair patch material has mechanical property suitable for clinical use, degradation rate matched with tissue repair and good cell compatibility, has wide clinical application prospect. The soft tissue repair patch is prepared by mixing the soft tissue repair patch material and cells and adopting a three-dimensional printing mode, the three-dimensional printing mode can control the printing precision of the soft tissue repair patch and meet the requirement of the soft tissue repair patch on a complex structure, the three-dimensional soft tissue repair patch with sufficient mechanical property and good cell activity can be prepared. The feasibility of the printing mode in the field of biological tissue repair is proved, and a foundation is laid for the in vivo research of the soft tissue repair patch. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a soft tissue repair patch made from the soft tissue repair patch material and cells; and (2) the preparation method of the soft tissue repair patch. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic structural view of the soft tissue repair patch, Bottom layer (1) Middle layer (2) Top layer (3)