▎ 摘　　要

NOVELTY - PH-sensitive oxidation graphene nanosheet coated mesoporous silicon dioxide medicine complementary metal-oxide-semiconductor (CMOS) composite nanoparticle comprises mesoporous silicon dioxide nanoparticles, cinnamaldehyde, oxidized graphene nanosheet and doxorubicin hydrochloride, where cinnamaldehyde is loaded inside the mesoporous silica nanoparticles, oxidized graphen nanosheets are coated on the surface of mesoporous silica nanoparticles and doxorubicin hydrochloride is loaded into the oxidized graphene nanosheet structure. USE - The composite nanoparticle is useful in the field of controlled release of medicines (claimed). ADVANTAGE - The composite nanoparticle has good biocompatibility, high drug-loading rate, less drug release in the neutral pH range; achieves drug responsive release in the low pH environment; improves the intracellular drug accumulation; enhances the treating effect of the medicine and reduces the toxic side effect. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing PH-sensitive oxidation graphene nanosheet coated mesoporous silicon dioxide medicine CMOS composite nanoparticle comprising (i) taking doxorubicin hydrochloride -loaded graphene oxide nanosheets and oxidized graphene nanosheet in a ratio of 1:1-1:8 to obtain mixed aqueous solution, stirring at room temperature for 12-48 hours, washing, centrifuging, and lyophilizing, doxorubicin-loaded graphene oxide nanosheets, where the graphene oxide nanosheets have a diameter of 100-200 nm; (ii) taking mesoporous silicon dioxide nanoparticles loaded with cinnamaldehyde to obtain surface aminated mesoporous Silica nanoparticles (a) adding hexadecyl trimethyl ammonium bromide, anhydrous ethanol and triethanolamine into water in the ratio of 0.14: 21 : 1,8: 2.1~1.14: 21 : 1,8: 2, heating, mixing and stirring, then adding tetraethyl orthosilicate, performing heating reaction under the temperature of 20-80 degrees C, repeatedly washing, centrifuging, vacuum drying to obtain the mesoporous template-containing silicon dioxide nanometer particle; (b)dispersing mesoporous silica nanoparticles containing templating agent in an acidic ethanol solution containing hydrochloric acid, and heating and refluxing at 60-80 degrees C for 24-48 hours, repeatedly washing, centrifuging and vacuum drying, removing the mesoporous silica nanoparticles of the templating agent, where hydrochloric acid-containing acidic ethanol solution accounts for 10-15% of the total solution volume and the unit is v/v, concentration of concentrated hydrochloric acid in the acidic ethanol solution is 36-38%, and the unit is wt.%/ wt.%/; and (c) adding mesoporous silica nanoparticles with templating agent to isopropanol, adding 3-aminopropyltriethoxysilane, and heating and refluxing at 60-80 degrees C for 24-48 hours, repeatedly washing, centrifuging, and vacuum drying to obtain surface aminated mesoporous silica nanoparticles and removing mesoporous silica nanoparticle of the templating agent, where the ratio of 3-aminopropyltriethoxysilane and isopropanol is 1:20:1000 to 1:20:1500, and the unit is m/vol.%/ vol.%, mixing surface-aminated mesoporous silica nanoparticle and cinnamaldehyde into a mixed ethanol solution at a mass ratio of 5:1-10:1, and stirring at room temperature for 12-24 hours, washing, centrifuging, vacuum drying to obtain mesoporous silica nanoparticles loaded with cinnamaldehyde and (iii) preparing a pH-responsive graphene oxide nanosheet coated mesoporous silica drug double-loaded composite nanoparticle, adding 0.05-0.1 g/ml cinnamaldehyde-loaded mesoporous silica nanoparticle aqueous solution and mixing with 0.05-0.1 g/ml doxorubicin-loaded graphene oxide nanosheet aqueous solution, stirring at room temperature, washing, centrifuging, and vacuum drying, where volume ratio of the cinnamaldehyde-loaded mesoporous silica nanoparticle aqueous solution and doxorubicin-loaded graphene oxide nanosheet aqueous solution is 1:1-1:3, concentration of the aqueous solution of mesoporous silica nanoparticles loaded with cinnamaldehyde is calculated as the mass of mesoporous silica nanoparticles and concentration of the doxorubicin-loaded graphene oxide nanosheet aqueous solution is calculated based on the mass of the graphene oxide nanosheet.