• 专利标题:   Exosome detecting micro-flow control chip based on oxidized graphene quenching nucleic acid aptamer comprises upper layer, lower layer, and bottom three layers orderly connected in series, and sample liquid layer set with sample inlet.
  • 专利号:   CN112206840-A
  • 发明人:   QIN J, CHEN W, SU W
  • 专利权人:   CAS DALIAN CHEM PHYSICAL INST
  • 国际专利分类:   B01L003/00, G01N021/64
  • 专利详细信息:   CN112206840-A 12 Jan 2021 B01L-003/00 202112 Pages: 11 Chinese
  • 申请详细信息:   CN112206840-A CN10622443 11 Jul 2019
  • 优先权号:   CN10622443

▎ 摘  要

NOVELTY - Exosome detecting micro-flow control chip based on oxidized graphene quenching nucleic acid aptamer comprises upper layer, lower layer, and bottom three layers orderly connected in series. The upper layer is sample liquid layer. The lower layer is nucleic acid aptamer liquid layer quenched by graphene oxide. The bottom surface is blank glass bottom plate. The sample liquid layer is set with sample inlet located at most upstream of whole sample liquid layer. The sample injection channel area is set between sample inlet and reaction tank for communication. The graphene oxide quenching nucleic acid aptamer liquid path layer is set with nucleic acid aptamer sample inlet of graphene oxide quenching. The nucleic acid aptamer liquid layer located at most upstream of whole oxidized graphene quenching. The reaction tank is set between nucleic acid aptamer feeding channel area and sample feeding channel area of graphene oxide quenching and vertically passing through whole chip for communication. USE - Used as exosome detecting micro-flow control chip based on oxidized graphene quenching nucleic acid aptamer. ADVANTAGE - The chip: has simple structure, convenient preparation and operation, fast speed, high efficiency and wide application range. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for reparing a micro-fluidic chip for detection of exosomes based on graphene oxide quenched nucleic acid aptamers. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic representation of the exosome detecting micro-flow control chip based on oxidized graphene quenching nucleic acid aptamer.