▎ 摘　　要

NOVELTY - Preparing thermally responsive magnetic hydrogel comprises e.g. dissolving 4-cyano-4-(phenylcarbonylthiothio)valeric acid-succinimide ester in dichloromethane, adding into the mixed solution, vacuum drying to obtain macromolecular chain transfer agent and dissolving in dioxane, adding a temperature-sensitive monomer, acrylic acid-N-succinimidyl ester, and a free radical initiator, reacting and vacuum drying to obtain temperature-sensitive polymer, dissolving the temperature-sensitive polymer in dichloromethane, adding triethylamine and small molecules with adhesive functional groups, reacting, precipitating, and vacuum drying to obtain temperature-sensitive copolymer, adding sodium polystyrene sulfate and hydrazine hydrate, filtering, freeze-drying, adding the two-dimensional nanosheet-polystyrene sodium sulfate complex and iron acetylacetonate to tetraethylene glycol and dissolving the temperature-sensitive copolymer in iron-loaded nanosheet aqueous solution. USE - The thermally responsive magnetic hydrogel is useful in assisting liver cancer resection and post-operative anti-reoccurenceapparatus (claimed). ADVANTAGE - The magnetic thermal responsive hydrogel has soft tissue adhesion properties. The preparation method is simple; has mild preparation conditions, and high biological safety. DETAILED DESCRIPTION - Preparing thermally responsive magnetic hydrogel comprises (a) dissolving polyethylene glycol and triethylamine in dichloromethane, introducing argon gas protection to obtain a mixed solution, (b) dissolving 4-cyano-4-(phenylcarbonylthiothio)valeric acid-succinimide ester in dichloromethane, adding dropwise to the mixed solution, stirring at room temperature for 10-24 hours, the obtained product settles in ether, and vacuum drying to obtain a macromolecular chain transfer agent, (c) dissolving the macromolecular chain transfer agent obtained in step (b) in dioxane, adding a temperature-sensitive monomer, acrylic acid-N-succinimidyl ester, and a free radical initiator, fully dissolving, protecting by argon gas, reacting at 50-90°C for 24-48 hours after three freeze-thaw cycles, settling the obtained product in ether for three times, and vacuum drying to obtain temperature-sensitive polymer, (d) dissolving the temperature-sensitive polymer in dichloromethane, adding triethylamine and small molecules with adhesive functional groups, fully dissolving, protecting by argon, reacting at room temperature for 12-48 hours, precipitating the obtained product twice in diethyl ether, and vacuum drying to obtain the temperature-sensitive copolymer, (e) adding the two-dimensional nanosheets into distilled water, ultrasonically dispersing uniformly, adding sodium polystyrene sulfate and hydrazine hydrate, reacting at 100°C for 24-48 hours, filtering and freeze-drying the obtained product to obtain a two-dimensional nanosheet-polystyrene sodium sulfate composite, adding the two-dimensional nanosheet-polystyrene sodium sulfate complex and iron acetylacetonate to tetraethylene glycol to obtain the ultrasonic dispersion, heating the solution to 270-300°C gradiently under argon protection, centrifuging, removing the supernatant to obtain aqueous solution of iron-loaded nanosheets, and (f) dissolving the temperature-sensitive copolymer into the iron-loaded nanosheet aqueous solution. An INDEPENDENT CLAIM is included for thermally responsive magnetic hydrogel prepared by above-mentioned method.