• 专利标题:   Preparing radionuclides for use as therapeutic agent for treatment of cancer, involves irradiating target aqueous suspension with neutron source, where at least some of target nuclide material absorbs neutrons from the neutron source.
  • 专利号:   US2022193276-A1, WO2022140234-A1, TW202236307-A, US11517633-B2
  • 发明人:   LAPKA J, SAMIA A J, NOLTING D D, CHARLTON W S
  • 专利权人:   UNIV TEXAS SYSTEM, UNIV TEXAS SYSTEM
  • 国际专利分类:   A61K051/12, C01B032/159, C01B032/174, C01B032/198, G21G001/06, H05H006/00, B01J020/20, B01J020/28, G21G001/00, B82Y040/00, B82Y005/00
  • 专利详细信息:   US2022193276-A1 23 Jun 2022 A61K-051/12 202261 English
  • 申请详细信息:   US2022193276-A1 US555839 20 Dec 2021
  • 优先权号:   US128609P, US278979P, US288890P, US555839

▎ 摘  要

NOVELTY - Preparing radionuclides involves irradiating a target aqueous suspension with a neutron source, where at least some of a target nuclide material absorbs neutrons from the neutron source to generate radionuclides that recoil and are adsorbed by a solid carbon nanostructured material to form loaded solid carbon nanostructured material, and the target aqueous suspension comprises the solid carbon nanostructured material, water, a surfactant, and the target nuclide material. USE - Methods for preparing radionuclides used as therapeutic agent for treatment of several types of cancer and as other nuclear medicine applications. No biological data given. ADVANTAGE - The methods provides radionuclides having a high specific activity, adresses the drawbacks like requirement of large Yb targets, costly chemical resins, potentially significant losses of both the Lu-177 (due to decay in the columns) and the unirradiated Yb, and can produce large volumes of radioactive waste. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a composition which comprises solid carbon nanostructured material having adsorbed radionuclides, where the solid carbon nanostructured material comprises carbon nanotubes, single walled carbon nanotubes, multiwalled carbon nanotubes, layered graphitic sheets, one or more fullerenes, and/or graphene, and where the adsorbed radionuclides comprise a radioactive cation having an atomic number from 21-83; (2) a suspension which comprises the composition, water, and a surfactant, and a target nuclide material; and (3) a composition which comprises radionuclides of an atom in concentrated form, where a ratio of the radionuclides of the atom to stable or longer-lived nuclides of the atom in the concentrated form is from 0.1-800 or where the concentrated form has a specific activity from 50-9000 GBq/mg.