▎ 摘　　要

NOVELTY - Modified load antibacterial hydrogel comprises 80-100 pts. wt. polyvinyl alcohol, 0.4-0.8 pts. wt. graphene oxide, 5-8 pts. wt. polyether amine D230 and 0.1-0.4 pts. wt. nano-silver. USE - The modified load antibacterial hydrogel is useful in artificial skin, antibacterial dressing and wound bandage (all claimed). ADVANTAGE - The hydrogel: has good biocompatibility; can be applied to the fields of artificial skin, antibacterial dressings and wound bandages; and provides potential application value in tissue engineering. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing modified load antibacterial hydrogel, comprising (i) adding 4.5 ml concentrated sulfuric acid, 1.5 g potassium persulfate powder and 1.5 g phosphorus pentoxide powder into 250 ml conical flask under ice bath condition, adding 3 g graphite powder, heating for 6 hours, cooling naturally to room temperature, diluting, filtering, washing to neutral, drying naturally at room temperature to obtain preprocessed sample, taking 1g pre-processed sample and 0.5 g sodium nitrate, adding 23 ml concentrated sulfuric acid solution, dripping 3 g potassium permanganate slowly in 3 hours, stirring continuously for 0.5 hours, stirring and reacting continuously for 2 hours, reacting at 38degrees Celsius for 0.5 h, heating to 95degrees Celsius to react for 0.5 h, adding 60 ml de-ionized water, stirring continuously and slowly, adding 15 ml (30%) hydrogen peroxide solution, reacting for 15 minutes, adding 40ml (1 mol/liter) hydrochloric acid solution, precipitating, carrying out low-speed centrifugation of the lower precipitate, washing and placing in a freeze dryer for continuous drying for 1 day to prepare graphene oxide powder; (ii) adding 0.1 g graphene oxide powder into 200 ml de-ionized water for mechanical stirring under the condition of 80degrees Celsius and processing ultrasonically and adding 10-15 g polyether amine D230 at 30 minutes to obtain the polyether amine D230 modified graphene oxide solution; (iii) configuring the polyvinyl alcohol solution with concentration of 0.1-0.5 g/ml in the constant temperature water bath, adding 1-2.5 ml polyether amine D230 modified graphene oxide solution into the 20 ml polyvinyl alcohol solution under the condition of 90degrees Celsius, stirring for 10 minutes and dispersing ultrasonically for 30 minutes to obtain the polyether amine D230 modified graphene oxide dispersion; and (iv) adding 1.5 ml (0.2 mol/liter) silver nitrate solution into the dispersion obtained in step (iii) in the constant temperature water bath of 60degrees Celsius, adding 0.2 ml (0.3 mol/liter) sodium hydroxide solution, stirring for 10 minutes, adding 0.5ml (0.1 mol/liter) sodium borohydride solution, processing ultrasonically for 30 minutes under the nitrogen atmosphere, pouring into the glass mold, freezing for 24 hours, unfreezing for 2 hours and freezing-thawing repeatedly for many times to obtain the hydrogel.