• 专利标题:   Radiolabeled oxidized graphene complex modified with polyethylene glycol useful in contrast agent for nuclear medicine testing, preferably positron emission tomography and in kit for detecting tumor e.g. blood cancer and colon cancer.
  • 专利号:   KR2017118496-A
  • 发明人:   JANG S C, HUH Y S, ROH C H
  • 专利权人:   UNIV INHA RES BUSINESS FOUND
  • 国际专利分类:   A61K051/04, B01J019/10, C01B031/04, C07C031/20, G21H005/02
  • 专利详细信息:   KR2017118496-A 25 Oct 2017 C01B-031/04 201783 Pages: 15
  • 申请详细信息:   KR2017118496-A KR046358 15 Apr 2016
  • 优先权号:   KR046358

▎ 摘  要

NOVELTY - Radiolabeled oxidized graphene complex modified with polyethylene glycol, is claimed. USE - The complex is useful in contrast agent for nuclear medicine testing, preferably positron emission tomography and in kit for detecting tumor (blood cancer, colon cancer, brain tumor, glioma, gliosarcoma, anaplastic astrocytoma, medulloblastoma, stomach cancer, lung cancer, small cell lung carcinoma, uterine cervical carcinoma, colon carcinoma, rectal cancer, chordoma, throat cancer, Kaposi sarcoma, lymphangiosarcoma, lymphatic endothelial sarcoma, colorectal cancer, endometrial carcinoma, ovarian cancer, breast cancer, pancreatic cancer, prostate cancer, renal cell carcinoma, liver cancer kind, cholangiocarcinoma, choriocarcinoma, spermocytoma, testicular tumor, Wilms tumor, Ewing's tumor, bladder cancer species, angiosarcoma, endothelioblastoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, mammary line sarcoma, cystadenosarcoma, carcinoid tumor of bronchus, medullary carcinoma, mast cell tumor, mesothelioma, synovioma, melanoma, leiomyoma, rhabdomyoma, nervous tissue, retinoblastoma, oligodendroglioma, acoustic neuroma, hemangioblastoma, pinealoma, ependymoma, craniopharyngioma, epidermoid carcinoma, embryonal carcinoma, squamous cell carcinoma, basal cell carcinoma, fibrosarcoma, mucocele, myxosarcoma, liposarcoma, sarcoenchondroma, osteogenic sarcoma and leukemia) (all claimed). ADVANTAGE - The complex specifically absorbed into cancer cells in vivo, has excellent stability, and can be easily synthesized. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for producing radiolabeled oxidized graphene complex modified with polyethylene glycol, comprising (a) preparing oxidized graphene nanoparticles modified with polyethylene glycol, and (b) radio-labeling the obtained nanoparticles.