• 专利标题:   Graphene-based drug carrier used for preparing photothermal therapeutic agent comprises mesoporous silica-surface modified polydopamine-coated reduced graphene oxide.
  • 专利号:   CN106581688-A
  • 发明人:   WU Y, SHAO L, ZHANG R
  • 专利权人:   NAT CENT NANOSCIENCE TECHNOLOGY CHINA
  • 国际专利分类:   A61K031/704, A61K041/00, A61K047/34, A61K047/52, A61P035/00
  • 专利详细信息:   CN106581688-A 26 Apr 2017 A61K-047/52 201741 Pages: 8 Chinese
  • 申请详细信息:   CN106581688-A CN10981262 08 Nov 2016
  • 优先权号:   CN10981262

▎ 摘  要

NOVELTY - Graphene-based drug carrier comprises mesoporous silica-surface modified polydopamine-coated reduced graphene oxide. The thickness of mesoporous silica layer is 2-50 nm. The thickness of polydopamine layer is 1-30 nm. USE - Graphene-based drug carrier used for preparing photothermal therapeutic agent (claimed). ADVANTAGE - The carrier has enhanced biocompatibility and increased photothermal absorption performance. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of graphene-based drug carrier comprising dispersing graphene oxide in pH 8-9 buffer solution, adding dopamine hydrochloride, heating at 50-90 degrees C for 4-48 hours to obtain polydopamine-coated reduced graphene oxide, dispersing polydopamine-coated reduced graphene oxide in aqueous solution, adding cationic surfactant, adjusting pH of mixture to 10-12, adding organosilane, and reacting at room temperature for 12-36 hours to obtain drug carrier.