• 专利标题:   Preparing gadolinumdiethylenetriamine pentaacetic-graphene oxide complex used as MRI contrast agent, comprises e.g. dissolving gadopentetic acid and graphene oxide in organic solvent and treating resultant with e.g. dicyclohexylcarbodiimide.
  • 专利号:   US2015005483-A1
  • 发明人:   LEE H Y, WANG L
  • 专利权人:   UNIV SUNGKYUNKWAN RES BUSINESS FOUND
  • 国际专利分类:   A61K049/10, C07F005/00
  • 专利详细信息:   US2015005483-A1 01 Jan 2015 A61K-049/10 201507 Pages: 6 English
  • 申请详细信息:   US2015005483-A1 US336868 21 Jul 2014
  • 优先权号:   KR091054

▎ 摘  要

NOVELTY - Preparing a gadolinumdiethylenetriamine pentaacetic-graphene oxide complex (GO-Gd-DTPA), comprises: (a) dissolving gadopentetic acid (Gd-DTPA) and graphene oxide (GO) in an organic solvent; (b) treating GO-Gd-DTPA with dicyclohexylcarbodiimide and dimethylaminopyridine to esterify the GO-Gd-DTPA; (c) bonding the esterified GO-Gd-DTPA with the graphene oxide in nitrogen gas to form a GO-Gd-DTPA (gadolinum-diethylenetriamine pentaacetic-graphene oxide) complex; and (d) separating the GO-Gd-DTPA complex using a filter. USE - The process is useful for preparing a gadolinumdiethylenetriamine pentaacetic-graphene oxide complex (claimed) which is useful as MRI contrast agents. ADVANTAGE - The process provides gadolinumdiethylenetriamine pentaacetic-graphene oxide complex which has low toxicity, high dispersibility and enhanced stability.