▎ 摘 要
NOVELTY - Preparing a gadolinumdiethylenetriamine pentaacetic-graphene oxide complex (GO-Gd-DTPA), comprises: (a) dissolving gadopentetic acid (Gd-DTPA) and graphene oxide (GO) in an organic solvent; (b) treating GO-Gd-DTPA with dicyclohexylcarbodiimide and dimethylaminopyridine to esterify the GO-Gd-DTPA; (c) bonding the esterified GO-Gd-DTPA with the graphene oxide in nitrogen gas to form a GO-Gd-DTPA (gadolinum-diethylenetriamine pentaacetic-graphene oxide) complex; and (d) separating the GO-Gd-DTPA complex using a filter. USE - The process is useful for preparing a gadolinumdiethylenetriamine pentaacetic-graphene oxide complex (claimed) which is useful as MRI contrast agents. ADVANTAGE - The process provides gadolinumdiethylenetriamine pentaacetic-graphene oxide complex which has low toxicity, high dispersibility and enhanced stability.