▎ 摘　　要

NOVELTY - A microdevice comprises FET comprising a substrate, a gate electrode, and a microfluidic channel including graphene, where the microfluidic channel is formed between drain electrodes (109) and source electrodes (108) on the substrate, and an aptamer functionalized on a surface of the graphene, aptamer is adapted for binding to the target analyte, and binding of the target analyte to the aptamer alters the conductance of the graphene. USE - Microdevice for monitoring a target analyte, such as insulin (all claimed), oxygen, lactase, hormones, cholesterol, medicaments, viruses, and ions, and other diseases, such as glycogen storage disease and hyperinsulinaemic hypoglycaemia. ADVANTAGE - The device has improved specificity and sensitivity, can characterize biomolecular interactions under different levels of ionic strength and temperature, can readily conform to the local tissue geometry, and minimize irritation and injury to a tissue or organ, such as an eye during the sensor placement, can enable highly reliable, continuous monitoring of glucose in bodily fluids, such as tears, blood, saliva, mucus, interstitial fluid, spinal fluid, intestinal fluid, amniotic fluid, lymphatic fluid, pericardial fluid, peritoneal fluid, pleural fluid, semen, vaginal secretions, sweat, and synovial fluid of the subject. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for a method for monitoring a target analyte using an aptamer, which involves placing a nanosensor in contact with target analytes, where the nanosensor comprises a first conductance element functionalized with an aptamer configured to detect the target analyte and a second conductance element that is insensitive to the target analyte, detecting a difference, if any in the conductance of the first and second conductance elements and determining a presence of the target analyte based on the detected difference. DESCRIPTION OF DRAWING(S) - The drawing shows a cross sectional view of a graphene based nanosensor. Flexible substrate (101) Nanosensor (102) Reference modules (104) Source electrode (108) Drain electrode (109)