• 专利标题:   New folic acid-phosphorylcholine oligomer-modified graphene oxide used for preparing drug for treating tumor.
  • 专利号:   CN107007871-A
  • 发明人:   ZHANG T, QIN Y, LIN R
  • 专利权人:   UNIV NANJING
  • 国际专利分类:   A61K031/704, A61K047/04, A61K047/22, A61K047/32, A61L024/00, A61L024/02, A61L024/06, A61P035/00
  • 专利详细信息:   CN107007871-A 04 Aug 2017 A61L-024/06 201775 Pages: 8 Chinese
  • 申请详细信息:   CN107007871-A CN10376468 24 May 2017
  • 优先权号:   CN10376468

▎ 摘  要

NOVELTY - Folic acid-phosphorylcholine oligomer-modified graphene oxide (I) is new. USE - Folic acid-phosphorylcholine oligomer-modified graphene oxide used for preparing drug for treating tumor (claimed). ADVANTAGE - The product can induce hepatic arterial thrombosis; plays a role in embolization of tumor tissue; kills cancer cells; has more simple and more excellent chemotherapy effect; and avoids side effect caused by chemotherapy medicine. DETAILED DESCRIPTION - Folic acid-phosphorylcholine oligomer-modified graphene oxide of formula (I) is new. R1,R3=H or CH3; R2,R4=CxH2x+1; x=2-4 where phosphorylcholine-containing acrylate and amino-containing acrylate are the two monomers involved in polymerization; and m:n=1-10. INDEPENDENT CLAIMS are included for: (A) preparation of folic acid-phosphorylcholine oligomer-modified graphene oxide; and (B) application of folic acid-phosphorylcholine oligomer-modified graphene oxide comprising loading anti-tumor chemotherapeutic agents on the surface of folic acid-phosphorylcholine oligomer-modified graphene for embolization of tumor blood vessels and release of antineoplastic agents.