• 专利标题:   Preparing porous silicon graphene quantum dot composite drug-carrying particle useful in preparing wound dressing for treating wound, comprises e.g. subjecting to surface washing pretreatment, electrochemically etching and stripping.
  • 专利号:   CN111686092-A
  • 发明人:   WU J, CUI Y, DUAN W
  • 专利权人:   UNIV ZHEJIANG
  • 国际专利分类:   A61K031/722, A61K038/18, A61K038/28, A61K047/04, A61K049/00, A61K009/51, A61L015/18, A61L015/20, A61L015/28, A61L015/32, A61L015/42, A61L015/44, A61P017/02, A61P003/10
  • 专利详细信息:   CN111686092-A 22 Sep 2020 A61K-009/51 202083 Pages: 17 Chinese
  • 申请详细信息:   CN111686092-A CN10565199 19 Jun 2020
  • 优先权号:   CN10565199

▎ 摘  要

NOVELTY - Preparing porous silicon graphene quantum dot composite drug-loaded particles comprises (i) (a) subjecting single crystal silicon wafer to surface washing pretreatment, electrochemically etching, electrochemical stripping, and weak oxidation activating to obtain porous silicon particles with fluorescence characteristics, (b) heating carboxy-containing carbon material at high temperature and adding deionized water to dilute to obtain graphene quantum dot solution with fluorescence characteristics, and (c) dispersing porous silicon particles in graphene quantum dot solution, shaking, centrifuging and cleaning to obtain porous silicon/graphene quantum dot composite particles, and (ii) dispersing porous silicon/graphene quantum dot composite particles into peptide drug solution with concentration of 0.5-5 mg/ml, shaking, centrifuging, and washing to obtain porous silicon/graphene quantum dot composite drug-loading particles loaded with drug molecules. USE - The method is useful in preparing porous silicon graphene quantum dot composite drug-carrying particle and preparing wound dressing for treating wound, preferably diabetic wounds and disease wounds (claimed). ADVANTAGE - Then particles has therapeutic and synergistic effect, which accelerates wound healing. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) porous silicon graphene quantum dot composite drug-loaded particle wound dressing, comprising using polymer wound dressing as flexible carrier, and coating porous silicon/graphene quantum dot composite drug-carrying particles on polymer wound dressing; (2) preparing porous silicon graphene quantum dot composite drug-carrying particle wound dressing, comprising dispersing porous silicon/graphene quantum dot composite drug-loading particles into raw material of the polymer dressing, adding silanized coupling agent with volume concentration of 0.1-0.3%, coating uniformly mixed solution on surface of polyurethane film, and forming chitosan gel to obtain wound dressing coated with porous silicon/graphene quantum dot composite drug-carrying particles; and (3) use of porous silicon graphene quantum dot composite drug-carrying particle wound dressing for treating wound, preferably diabetic wounds and disease wounds.