• 专利标题:   Hydrogel material used as bone-filled biomedical material used for manufacturing inorganic non-metallic gel scaffold in e.g. tissue engineering, is assembly of inorganic non-metallic particles with preset size forming hydrogel network having microscopic pores with preset pore diameter.
  • 专利号:   CN113336536-A, CN113336536-B, WO2022252526-A1
  • 发明人:   WANG H, DOU Z, CHEN K, LI X, GONG C, SUN K
  • 专利权人:   UNIV DALIAN TECHNOLOGY, UNIV DALIAN TECHNOLOGY
  • 国际专利分类:   B29C064/386, B29C067/04, B33Y010/00, B33Y050/00, B33Y070/10, C03B019/06, C04B035/14, C04B035/622, C04B035/624, B33Y070/00
  • 专利详细信息:   CN113336536-A 03 Sep 2021 C04B-035/14 202188 Pages: 37 Chinese
  • 申请详细信息:   CN113336536-A CN10601607 31 May 2021
  • 优先权号:   CN10601607

▎ 摘  要

NOVELTY - A hydrogel material is assembly of 2-80 wt.% inorganic non-metallic particles with a size of 10 nm to 20 mu m forming a hydrogel network having microscopic pores with a pore diameter of 0.1-30 mu m. USE - The hydrogel material is useful as bone-filled biomedical material for injectable, moldable and drug sustained-release carrier, which is useful for manufacturing inorganic non-metallic gel scaffold used in tissue engineering as bone repair scaffold, cartilage repair scaffold, loaded bioactive protein drug, bioactive substance drug molecule or mesenchymal stem cells, endothelial cell and Schwann cell scaffold, or in electronic device including supercapacitor, battery, solar cell, piezoelectric sensor, optoelectronic sensor, chemical sensing agent, biosensor, and electronic skin sensor device (all claimed). ADVANTAGE - The hydrogel material is directly applied to inorganic non-metallic additive manufacturing technology without additive or crosslinking agent. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) an inorganic non-metallic gel scaffold prepared by additive manufacture of the hydrogel material, and has interpenetrating pores formed by stacking fibers with a pore diameter of 50-1000 mu m, and a porosity of 20-80%. The surface of the scaffold fiber has microscopic pores with a pore diameter of 3-80 nm, a specific surface area of 50-500 m2/g, and a fracture mechanical strength of 2-25 MPa; and (2) preparation of the gel scaffold, which involves (A) obtaining a three-dimensional printing ink by using gel ink raw material, (B) building a model through modeling software, and subjecting the established model to hierarchical slicing processing in combination with slicing software, (C) inputting the designed model into a printer, setting the number of printing lines, printing speed and the number of printing layers for each layer of the model, and packaging the gel ink raw materials in the syringe barrel of the printer for layer-by-layer printing to form a gel model blank, and (D) adding the gel model blank to a sintering furnace to adjust the sintering temperature to obtain a corresponding customized three-dimensional porous inorganic non-metallic scaffold.