• 专利标题:   Preparing artificial skin receptor by grinding monolayer graphene, adding nitric acid, mixing aqueous silk fibroin solution and graphene solution, evaporating monocrystalline silicon wafer, coating mixture and immersing in methanol.
  • 专利号:   CN107412880-A
  • 发明人:   WAN J, WANG J, HU Z, WANG B, PENG Z
  • 专利权人:   UNIV ZHEJIANG SCI TECH
  • 国际专利分类:   A61L027/08, A61L027/18, A61L027/22, A61L027/50, A61L027/60, C07K001/14, C07K014/435, C12P021/06
  • 专利详细信息:   CN107412880-A 01 Dec 2017 A61L-027/60 201807 Pages: 8 Chinese
  • 申请详细信息:   CN107412880-A CN10626812 28 Jul 2017
  • 优先权号:   CN10626812

▎ 摘  要

NOVELTY - Method of preparing artificial skin receptor involves grinding monolayer graphene, then adding nitric acid solution, boiling the mixture, washing the treated monolayer graphene, drying, adding deionized water, drying silk fibroin, adding deionized water, mixing the aqueous silk fibroin solution, graphene solution, glycerol and polyethylene glycol, evaporating monocrystalline silicon wafer into substrate membrane, spin coating the mixture on the substrate membrane, immersing in methanol aqueous solution and drying to obtain the product. USE - The method is useful for preparing artificial skin receptor (claimed). ADVANTAGE - The method enables preparation of artificial skin receptor which is transparent and flexible, has excellent physical and mechanical properties and external force response performance and does not stimulation or harm the human body. DETAILED DESCRIPTION - Method of preparing artificial skin receptor involves (a) grinding monolayer graphene, then adding nitric acid solution and boiling the mixture for 20-60 minutes, (b) washing the treated monolayer graphene with deionized water until the solution is neutral, drying and determining the sample concentration, (c) adding monolayer graphene into deionized water in accordance with the concentration of the sample and ultrasonicaly treating to obtain uniformly dispersed 0.1 wt.% monolayer graphene solution, (d) preparing silk fibroin, (e) drying the silk fibroin, adding deionized water and ultrasonically treating to obtain a uniformly dispersed 0.08-0.12 wt.% aqueous silk fibroin solution, (f) mixing the aqueous silk fibroin solution, graphene solution, glycerol and polyethylene glycol, adjusting the pH of the mixture to 9.5-10.5 with aqueous ammonia and ultrasonically treating to obtain uniformly dispersed silk fibroin-graphene-glycerol-polyethylene glycol mixture, (g) adding monocrystalline silicon wafer into an evaporating dish, adding trimethylchlorosilane liquid, closing the evaporating dish and evaporating 8-12 minutes to obtain non-sticky substrate membrane, (h) spin coating silk fibroin-graphene-glycerol-polyethylene glycol mixture on the substrate membrane to obtain conductive intermediate membrane and drying at 40-80 degrees C and (i) immersing the dried membrane in 85-95 vol.% methanol aqueous solution at low-temperature for 1-3 hours for annealing and drying the membrane at room temperature to obtain the product.