• 专利标题:   Scaffold used for skeletal muscle regeneration, comprises nanofibers comprising mixture of graphene nanoplatelets and biocompatible polymer.
  • 专利号:   US2021402054-A1
  • 发明人:   LAURENCIN C, SAVEH S N
  • 专利权人:   UNIV CONNECTICUT
  • 国际专利分类:   A61L027/08, A61L027/18, A61L027/22, A61L027/24, A61L027/50
  • 专利详细信息:   US2021402054-A1 30 Dec 2021 A61L-027/08 202213 English
  • 申请详细信息:   US2021402054-A1 US352189 18 Jun 2021
  • 优先权号:   US041594P, US352189

▎ 摘  要

NOVELTY - Scaffold (I) comprises nanofibers, which comprise a mixture of graphene nanoplatelets and a biocompatible polymer, where the scaffold comprises a random orientation, and the nanofiber comprises uniaxial nanostructures, and an orientation of the nanostructure is ordered at the orientation of (I), and the orientation is ordered in a direction of the orientation (I). The scaffold further comprises an orientation ordered at a direction (A), where the orientation ordered is ordered by the orientation and orientation is arranged in the direction of (A). USE - Scaffold is useful for regenerating skeletal muscle. The skeletal muscle is muscle stem cells that participate in myogenesis process by differentiating into muscle fibers. ADVANTAGE - The scaffold is biocompatible and utilizes graphene nanoplatelets, which exhibit improved mechanical properties, such as tensile strength, modulus of elasticity, elongation, and/or tensile modulus in comparison to uniaxial nanofibers, and have a high degree of mechanical strength and elastic modulus, and a low degree of porosity, and thus are suitable for use as scaffolds for repairing a muscle or tendon tear in a minimally invasive manner, and can be easily implanted into a human body without the need for invasive surgical procedures. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) a method for making the scaffold, which involves (a) mixing graphene nanoplatelets in an organic solvent to produce a mixture, (b) dissolving a biocompatible polymer in the mixture of (a) to produce a dissolved polymer mixture, (c) dispensing the dissolved polymer mixture through an aperture exposed to an electrical potential to produce nanofibers, and (d) collecting the nanofibers; and (2) a method for repairing a muscle or tendon tear, which involves implanting a scaffold, where one end of the scaffold is attached to a proximal end of a torn muscle or tendon and another end of the scaffold is attached to a distal end of a torn muscle or tendon. DESCRIPTION OF DRAWING(S) - The drawing shows a posterior view of a rotator cuff anatomy and involved tendons including the supraspinatus, infraspinatus, teres minor, and subscapularis.