▎ 摘　　要

NOVELTY - Production of polymer-functionalized and drug-loaded reduced graphene oxide material involves adding potassium persulfate to a concentrated strong acid, adding a desiccant and graphite, stirring, washing, filtering and drying to obtain a precursor, homogenizing the precursor with sodium nitrate, adding to a vessel containing concentrated strong acid, adding an oxidizing agent, distilled water and hydrogen peroxide, filtering and drying the filtrate to obtain a graphite oxide, preparing an aqueous dispersion of graphite oxide using graphite oxide, placing in an ultrasonic bath, centrifuging, collecting supernatant, placing in ultrasonic bath, centrifuging and lyophilizing to obtain dispersion of graphene oxide, diluting with distilled water, adding an aqueous dispersion of a polymer, adding a reducing agent, washing with distilled water, adding a dispersion of a drug in a solubilizing mixture, macerating, ultrasonically-dispersing, stirring in the absence of light, and centrifuging. USE - Production of polymer-functionalized and drug-loaded reduced graphene oxide material is used for improving availability of drug e.g. amphotericin B, miltefosine or rifampicin to treat cutaneous leishmaniasis (all claimed), leprosy, skin cancer and malassezia. ADVANTAGE - The polymer-functionalized and drug-loaded reduced graphene oxide material does not cause side effects. DETAILED DESCRIPTION - Production of polymer-functionalized and drug-loaded reduced graphene oxide material involves (i) adding potassium persulfate to a strong acid concentrated at 95-99 wt.% at 80° C, adding a desiccant under stirring, adding graphite, stirring the reaction mixture, washing the mixture with distilled water for 3-4 times until a pH value reaches 7-8, filtering and drying the filtered product to obtain a precursor, (ii) homogenizing the precursor with sodium nitrate, adding to a vessel containing strong acid concentrated at 95-99 wt.% in cold weight, stirring, adding an oxidizing agent to the mixture while stirring, increasing the temperature and maintaining for preset time, adding distilled water to the mixture while stirring, adding hydrogen peroxide, filtering the mixture, washing the filtered product with 10 vol.% hydrochloric acid solution, filtering and drying the filtrate to obtain a graphite oxide, (iii) preparing an aqueous dispersion of graphite oxide having a concentration of 3.5-4 mg/mL using graphite oxide, placing in an ultrasonic bath, centrifuging, collecting the supernatant and sieving the bottom product, collecting the solid from the sieve through washing with the supernatant, placing in the ultrasonic bath, centrifuging the dispersion and lyophilizing the supernatant which is a dispersion of graphene oxide, (iv) placing the dispersion of graphene oxide having a concentration of 3.5-4 mg/mL in the ultrasonic bath, diluting with distilled water, adding an aqueous dispersion of a polymer having a concentration of 18-19 g/L, stirring, adding a reducing agent while stirring, washing the solid with distilled water until the filtrate reaches a pH value of 7-8, purifying and lyophilizing the solid to obtain a clean, dry material, and (v) adding a dispersion of a drug in a solubilizing mixture having a pH value of 7.4-8 and a concentration of 40-100 mg/L to 50-150.5 mg clean, dry material, macerating, ultrasonically-dispersing, stirring the dispersion at room temperature in the absence of light, and centrifuging for 3-5 minutes. An INDEPENDENT CLAIM is included for the polymer-functionalized and drug-loaded reduced graphene oxide material, which comprises 35-40 wt.% nitrogen-doped graphene, 40-46 wt.% polymer and 8-10 wt.% drug.