• 专利标题:   Temperature-controlled antipyretic patch, comprises component A comprising silicone gel, inhibitor, filling agent, phase-change polymer material containing antipyretic and analgesic, and transdermal agent, and component B comprising silicone gel, catalyst, filling agent, and heat-conducting material.
  • 专利号:   CN116172982-A
  • 发明人:   ZHU L, ZHU Q, LAN Q, SHEN L, ZHAO S, JIANG P
  • 专利权人:   GUANGXI RAN BIOTECH CO LTD
  • 国际专利分类:   A61K031/192, A61K031/616, A61K045/00, A61K047/02, A61K047/10, A61K047/32, A61K047/34, A61K047/69, A61K009/70, A61P029/00
  • 专利详细信息:   CN116172982-A 30 May 2023 A61K-009/70 202354 Chinese
  • 申请详细信息:   CN116172982-A CN11145882 20 Sep 2022
  • 优先权号:   CN10799589

▎ 摘  要

NOVELTY - Temperature-controlled antipyretic patch comprises component A and B at ratio of 1-10:1. The component A comprises 50-110 pts. wt. silicone gel, 0-1.5 pts. wt. inhibitor, 10-20 pts. wt. filling agent, 10-20 pts. wt. phase-change polymer material containing antipyretic and analgesic, and 0-1.5 pts. wt. transdermal agent. The component B comprises 0-60 pts. wt. silicone gel, 5-10 pts. wt. catalyst, 20-25 pts. wt. filling agent, and 0-10 pts. wt. heat-conducting material. USE - Temperature-controlled antipyretic patch. ADVANTAGE - The silica gel in patch can be cured at room temperature, which meets the technological requirements for building an intelligent temperature-controlled drug release system. The patch avoids the melting of phase-change polymer material containing antipyretic and analgesic drugs in the heating preparation environment, which will affect the clathrate structure and drug release rate. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing the temperature-controlled antipyretic patch comprising mixing the component A to the component B, rapidly stirring and mixing at 26℃ for 5 minutes, coating on a backing material, vulcanizing for 5-10 minutes, and cutting according to specifications to obtain the temperature-controlled antipyretic patch.