• 专利标题:   Directional cartilage repair system based on PDA-PAni-graphene oxide/OHA/Gelatin/DCS hydrogel, comprises conductive hydrogel, sterile wire and pulsed DC power supply.
  • 专利号:   CN115192772-A, CN115192772-B
  • 发明人:   YU X, ZHOU H, ZHANG W, XU J, TENG W, CHEN J, ZHANG Z, YE Z, JIN X
  • 专利权人:   UNIV ZHEJIANG
  • 国际专利分类:   A61L027/02, A61L027/18, A61L027/20, A61L027/22, A61L027/50, A61L027/52, A61L027/58
  • 专利详细信息:   CN115192772-A 18 Oct 2022 A61L-027/20 202203 Chinese
  • 申请详细信息:   CN115192772-A CN10976885 15 Aug 2022
  • 优先权号:   CN10976885

▎ 摘  要

NOVELTY - Directional cartilage repair system based on PDA-PAni-graphene oxide/OHA/Gelatin/DCS hydrogel, comprises conductive hydrogel, sterile wire and pulsed DC power supply, and conductive hydrogel is the use of graphene oxide, aniline, dopamine as a raw material to prepare a nano-conductive functional filler with a multi-layer core-shell structure, mixing with aldehyde-based hyaluronic acid, catechol-modified chitosan, gelatin compound, an injectable conductive hydrogel material PDA-PAniGO/OHA/Gelatin/DCS prepared by Schiff base reaction. USE - Used as directional cartilage repair system based on PDA-PAni-graphene oxide/OHA/Gelatin/DCS hydrogel. ADVANTAGE - The hydrogel material has excellent conductivity, injectable, cartilage adhesion, biological compatibility and biodegradable performance, by in-situ injection, it can realize gelation, two gel of the gel are connected with sterile lead and pulse direct current power supply. It can provide pulse-direct current electric stimulation effect, it is used for improving articular cartilage defect orientation repairing reconstruction.