• 专利标题:   Fabricating sequencing device comprises applying graphene monolayer onto substrate, patterning graphene monolayer, depositing metal electrodes, and depositing molecular bridges across the nanogaps.
  • 专利号:   WO2023023143-A1, US2023059925-A1
  • 发明人:   VALENCIA D A, MORAN I W
  • 专利权人:   CHARLES STARK DRAPER LAB INC, CHARLES STARK DRAPER LAB INC
  • 国际专利分类:   B82Y015/00, C12Q001/00, G01N027/327, G01N027/414, G01N033/487, B82Y040/00, C12Q001/6869
  • 专利详细信息:   WO2023023143-A1 23 Feb 2023 G01N-027/414 202319 Pages: 34 English
  • 申请详细信息:   WO2023023143-A1 WOUS040583 17 Aug 2022
  • 优先权号:   US234574P, US889793

▎ 摘  要

NOVELTY - Fabricating sequencing device comprises applying graphene monolayer onto a substrate to form a universal gate, patterning graphene monolayer into graphene nanoribbons separated by nanogaps, depositing metal electrodes onto the graphene nanoribbons to form field-effect transistors (FET) array, and depositing molecular bridges across the nanogaps, where at least one of the molecular bridges has cross section no greater than 2 nanometers and a ballistic conductivity that is the same or substantially the same as the ballistic conductivity of a graphene nanoribbon. USE - The method is useful for: fabricating a sequencing device used to sequence DNA molecule. ADVANTAGE - The method simplifies sequencing, cost effective and analyzes using simple environmental sensitive tools. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: equencing device comprising substrate supporting graphene monolayer, molecular bridge at nanogap defined in the graphene monolayer, and electrodes for providing electron transport along the molecular bridge, where the molecular bridge has cross-section of 1-2 nanometers and has ballistic conductivity that is the same or substantially the same as that of a nanographene ribbon; ystem sequencing system, comprising a flow chamber, and a Fano resonator sequencing device comprising molecular bridge at nanogap defined in a graphene monolayer, where the molecular bridge has a cross-section no greater than 2 nanometers and has a ballistic conductivity that is the same or substantially the same as that of a nanographene ribbon; and equencing a molecule, comprising passing a sample comprising the molecule across a molecular bridge having a cross-section of 2 nanometers and ballistic conductivity that is the same or substantially the same as the ballistic conductivity of a graphene nanoribbon, and conducting Fano resonance transmission analysis to identify the molecule or a component.