• 专利标题:   System useful for detecting pathogen, comprises sensor configured to generate signal indicating conductivity of sensor, processor, and memory comprising instructions to receive signal, determine change in conductivity and detect pathogen.
  • 专利号:   WO2023003927-A1
  • 发明人:   DANIELS K M, KIM S, RZASA J R
  • 专利权人:   UNIV MARYLAND COLLEGE PARK
  • 国际专利分类:   C12Q001/04, G16H050/20
  • 专利详细信息:   WO2023003927-A1 26 Jan 2023 C12Q-001/04 202314 Pages: 39 English
  • 申请详细信息:   WO2023003927-A1 WOUS037666 20 Jul 2022
  • 优先权号:   US223919P

▎ 摘  要

NOVELTY - System (100) comprises (a) a sensor (300) configured to generate a signal indicating a conductivity of the sensor, (b) a processor, and (c) a memory comprising instructions stored on memory, which when executed by the processor cause the system to (i) receive the signal from the sensor, (ii) determine a change in a conductivity of the sensor based on the signal, and (iii) determine the presence or the absence of a pathogen based on the determined change in conductivity. USE - The system is useful for detecting a pathogen. The sensor is useful for detecting an antigen (claimed). The pathogen is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19). ADVANTAGE - The system is portable to enable convenient, accurate and/or widespread testing capabilities, and detects the presence or absence of the antigen in real-time based on a change in the conductivity of the sensor. The system is highly accurate and ultrafast, and provides a sensitivity that is significantly lower than the limit of detection for existing immunoassays and other biosensors, particularly responds to as low as one attogram of the antigen through wireless sensing. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: a sensor comprising (a) a first layer comprising a non-conductive material, (b) a second layer comprising a conductive material having an antibody bonded to it, and (c) a set of electrodes arranged on the second layer; and a computer-implemented method for detecting pathogen involves (a) determining a change in a conductivity of a graphene-based sensor, and (b) determining the presence or the absence of a pathogen based on the determined change in conductivity. DESCRIPTION OF DRAWING(S) - The drawing shows the schematic diagram of system for detecting pathogen. 100System 110Connector 120Touch screen 130Display 300Sensor