• 专利标题:   Slow-release growth factor hydrogel bracket of graphene oxide composite platelet-rich plasma used for biological medical field of tendon bone tissue repair comprises graphene oxide aqueous solution, platelet-rich plasma, and thrombin.
  • 专利号:   CN112773943-A
  • 发明人:   BAO D, ZENG S, SHI J, QIN B, GONG M, FU S, DENG K, LIU G, WANG X, LU Z, LUO R, XIONG Z
  • 专利权人:   UNIV SOUTHWEST MEDICAL TRADITIONAL CHINE
  • 国际专利分类:   A61L027/08, A61L027/22, A61L027/36, A61L027/40, A61L027/52, A61L027/54
  • 专利详细信息:   CN112773943-A 11 May 2021 A61L-027/52 202151 Pages: 12 Chinese
  • 申请详细信息:   CN112773943-A CN10034302 11 Jan 2021
  • 优先权号:   CN10034302

▎ 摘  要

NOVELTY - Slow-release growth factor hydrogel bracket of graphene oxide composite platelet-rich plasma comprises graphene oxide aqueous solution, platelet-rich plasma, and thrombin. USE - The slow-release growth factor hydrogel bracket of graphene oxide composite platelet-rich plasma is used for biological medical field of tendon bone tissue repair process. ADVANTAGE - The bracket solves the prior art problem of unstable structure, poor biomechanical property, low tissue adhesion ability, unstable growth factor release, short half life, incapability of acting on focus for a long time, and difficulty to continuously repair the tissue. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of the slow-release growth factor hydrogel bracket of graphene oxide composite platelet-rich plasma comprising extraction of arterial blood of the animal and injecting anticoagulant into the arterial blood; centrifuging the arterial blood and separating the blood plasma; centrifuging the plasma and separating the platelet rich plasma; fully mixing the graphene oxide powder with PBS buffer solution, and preparing the graphene oxide aqueous solution with needed concentration; mixing the platelet-rich plasma and graphene oxide aqueous solution and putting in prefabricated model; and adding thrombin to form a slow-release growth factor hydrogel bracket of graphene oxide composite platelet-rich plasma.