• 专利标题:   Preparing phospholipid-graphene oxide composite material, for loading and controlled release of drug or gene, comprises e.g. reacting graphene oxide aqueous solution, prepared liposome solution and reducing agent solution, and centrifuging.
  • 专利号:   CN102935233-A
  • 发明人:   LIU J, LIU Y, WANG T, WANG E
  • 专利权人:   CHINESE ACAD SCI CHANGCHUN INST APPL CHE
  • 国际专利分类:   A61K047/04, A61K047/24, C12N015/63
  • 专利详细信息:   CN102935233-A 20 Feb 2013 A61K-047/24 201344 Pages: 11 Chinese
  • 申请详细信息:   CN102935233-A CN10436172 05 Nov 2012
  • 优先权号:   CN10436172

▎ 摘  要

NOVELTY - Preparing phospholipid-graphene oxide composite material, comprises: (a) preparing negatively charged phospholipids liposome solution, and (b) mixing graphene oxide aqueous solution and prepared liposome solution in an ultrasonic water bath of 10-60 degrees C to form uniform dispersion liquid, stirring and adding reducing agent aqueous solution, reacting for 2-36 hours at 35-90 degrees C in the water bath, performing reduction of graphene oxide, separating by centrifugation, and washing to remove excess liposome and reducing agent to obtain phospholipid membrane-graphene oxide composite material. USE - The composite material is useful for loading and controlled release of drug or gene. ADVANTAGE - The composite material has high specific surface area, and is provided with good dispersibility and stability in the aqueous phase. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for phospholipid membrane-graphene composite material prepared by the method mentioned above.